RNA interference

Monsanto is trying to use genetic technology to kill honeybee pests.

RNA can also “silence” specific genes, preventing an organism from using them to make proteins. In 1998 scientists discovered that they could engineer stretches of double-stranded RNA to do the same thing. As a lab technique, RNA interference—or RNAi—turned out to be useful for learning about genes by turning them off. It also showed promise in fighting viruses, cancers, and even harmful pests and parasites. The researchers at the seminar were talking about using RNAi to prevent mosquitoes from spreading malaria, but that gave Hayes another idea. “I thought, could this be adapted to honeybee predator control?” In other words: to kill mites…

Traditional pesticides act like chemical backhoes, killing their targets (beetles, weeds, viruses) but harming good things along the way (beneficial insects, birds, fish, humans). RNAi, in theory, works instead like a set of tweezers, plucking its victims with exquisite specificity by clicking into sequences of genetic code unique to that organism. “If you could design an ideal pesticide, this is the stuff you’re looking for,” says Pamela Bachman, a toxicologist at Monsanto.

 

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