Tag Archives: antibiotic resistance

flesh eating bacteria: worry or not worry?

1 Reply

If you are one of the people who gets flesh eating bacteria, it is horrible. This article is about a person who got a minor scrape in the Gulf of Mexico, lost her leg, and was lucky to live. But here are the numbers:

Cases of V. vulnificus are rare. Between 150 and 200 are reported to the Centers for Disease Control and Prevention every year, with about 20% resulting in death. Most are in states along the Gulf of Mexico, but, in 2019, 7% were on the Pacific Coast. Florida averages about 37 cases and 10 deaths a year.

But a rise in cases nationally and the spread of the disease to states farther north — into coastal communities in states such as Connecticut, New York, and North Carolina — have heightened concerns about the bacterium, which can result in amputations or extensive removal of tissue even in those who survive its infections. And warmer coastal waters caused by climate change, combined with a growing population of older adults, may result in infections doubling by 2060, a study in Scientific Reports warned earlier this year.

Alternet, orignally in Tampa Bay Times

My heart certainly goes out to this person, the other 149-199 people per year who get this, and the other 299 to 399 per year who may get it by 2060. I am going to continuing worrying most about things that kill tens or hundreds of thousands of people each year. And I am going to keep in mind that being so fearful of the outside world I become a couch potato would also be very risky for my health.

April 2023 in Review

Leave a reply

I made several posts with numbers on crime, suicide, and poverty. The U.S. is a violent, unequal country. I’ve talked about these issues a lot, so far without any noticeable effect on our political class. So I’ve picked some other things below.

Most frightening and/or depressing story: Chemicals, they’re everywhere! And there were 20,000 accidents with them in 2022 that caused injuries, accidents, or death. Some are useful, some are risky, and some are both. We could do a better job handling and transporting them, we could get rid of the truly useless and dangerous ones, and we could work harder on finding substitutes for the useful but dangerous ones. And we could get rid of a corrupt political system where chemical companies pay the cost of running for office and then reward candidates who say and do what they are told.

Most hopeful story: There has been some progress on phages, viruses intentionally designed to kill antibiotic-resistant bacteria. Also, anti-aging pills may be around the corner.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: I had heard the story of the Google engineer who was fired for publicly releasing a conversation with LaMDA, a Google AI. But I hadn’t read the conversation. Well, here it is.

December 2020 in Review

Leave a reply

2020 is officially in the books!

Most frightening and/or depressing story: The “Map of Doom” identifies risks that should get the most attention, including antibiotic resistance, synthetic biology (also see below), and some complex of climate change/ecosystem collapse/food supply issues.

Most hopeful story: The Covid-19 vaccines are a modern “moonshot” – a massive government investment driving scientific and technological progress on a particular issue in a short time frame. Only unlike nuclear weapons and the actual original moonshot, this one is not military in nature. (We should be concerned about biological weapons, but let’s allow ourselves to enjoy this victory and take a quick trip to Disney Land before we start practicing for next season…) What should be our next moonshot, maybe fusion power?

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: Lists of some key technologies that came to the fore in 2020 include (you guessed it) mRNA vaccines, genetically modified crops, a variety of new computer chips and machine learning algorithms, which seem to go hand in hand (and we are hearing more about “machine learning” than “artificial intelligence” these days), brain-computer interfaces, private rockets and moon landings and missions to Mars and mysterious signals and micro-satellites and UFOs, virtual and mixed reality, social media disinformation and work-from-home technologies. The wave of self-driving car hype seems to have peaked and receded, which probably means self-driving cars will probably arrive quietly in the next decade or so. I was surprised not to see cheap renewable energy on any lists that I came across, and I think it belongs there. At least one economist thinks we are on the cusp of a big technology-driven productivity pickup that has been gestating for a few decades.

bacteria, viruses, and fungi, oh my!

Leave a reply

In the category of new diseases to worry about, and just in case you have not yet perused the latest issue of the Journal of Fungi, Candida auris is a really dangerous yeast fungus making the rounds in hospitals.

On the Origins of a Species: What Might Explain the Rise of Candida auris?

Candida auris is an emerging multidrug-resistant yeast first described in 2009 that has since caused healthcare-associated outbreaks of severe human infections around the world. In some hospitals, it has become a leading cause of invasive candidiasis. C. auris is markedly different from most other pathogenic Candida species in its genetics, antifungal resistance, and ability to spread between patients. The reasons why this fungus began spreading widely in the last decade remain a mystery. We examine available data on C. auris and related species, including genomic epidemiology, phenotypic characteristics, and sites of detection, to put forth hypotheses on its possible origins. C. auris has not been detected in the natural environment; related species have been detected in in plants, insects, and aquatic environments, as well as from human body sites. It can tolerate hypersaline environments and higher temperatures than most Candida species. We explore hypotheses about the pre-emergence niche of C. auris, whether in the environmental or human microbiome, and speculate on factors that might have led to its spread, including the possible roles of healthcare, antifungal use, and environmental changes, including human activities that might have expanded its presence in the environment or caused increased human contact.

breakthroughs in antibiotic resistance

Leave a reply

There are potential breakthroughs against antibiotic-resistant bacteria, which I think is good as I’ve been coughing up some kind of alien green goo for about a week now.

An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities

Antibiotic-resistant infections are predicted to kill 10 million people per year by 2050, costing the global economy $100 trillion. Therefore, there is an urgent need to develop alternative technologies. We have engineered a synthetic peptide called clavanin-MO, derived from a marine tunicate antimicrobial peptide, which exhibits potent antimicrobial and immunomodulatory properties both in vitro and in vivo. The peptide effectively killed a panel of representative bacterial strains, including multidrug-resistant hospital isolates. Antimicrobial activity of the peptide was demonstrated in animal models, reducing bacterial counts by six orders of magnitude, and contributing to infection clearance. In addition, clavanin-MO was capable of modulating innate immunity by stimulating leukocyte recruitment to the site of infection, and production of immune mediators GM-CSF, IFN-γ and MCP-1, while suppressing an excessive and potentially harmful inflammatory response by increasing synthesis of anti-inflammatory cytokines such as IL-10 and repressing the levels of pro-inflammatory cytokines IL-12 and TNF-α. Finally, treatment with the peptide protected mice against otherwise lethal infections caused by both Gram-negative and -positive drug-resistant strains. The peptide presented here directly kills bacteria and further helps resolve infections through its immune modulatory properties. Peptide anti-infective therapeutics with combined antimicrobial and immunomodulatory properties represent a new approach to treat antibiotic-resistant infections.