Tag Archives: longevity

April 2023 in Review

I made several posts with numbers on crime, suicide, and poverty. The U.S. is a violent, unequal country. I’ve talked about these issues a lot, so far without any noticeable effect on our political class. So I’ve picked some other things below.

Most frightening and/or depressing story: Chemicals, they’re everywhere! And there were 20,000 accidents with them in 2022 that caused injuries, accidents, or death. Some are useful, some are risky, and some are both. We could do a better job handling and transporting them, we could get rid of the truly useless and dangerous ones, and we could work harder on finding substitutes for the useful but dangerous ones. And we could get rid of a corrupt political system where chemical companies pay the cost of running for office and then reward candidates who say and do what they are told.

Most hopeful story: There has been some progress on phages, viruses intentionally designed to kill antibiotic-resistant bacteria. Also, anti-aging pills may be around the corner.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: I had heard the story of the Google engineer who was fired for publicly releasing a conversation with LaMDA, a Google AI. But I hadn’t read the conversation. Well, here it is.

anti-aging pills

Anti-aging pills will hit the market in about five years, according to “an expert” named Andrew Steele. Metformin is one being mentioned. Another is a “combination of datasinib, used for chemotherapy, and quercetin, a molecule found in fruits and vegetables.” A Jeff Bezos company is working on “cell therapies that can halt and eventually reverse the process of aging.”

For my body and brain, which are both in their mid- to late-40s, the aging train seems to have left the station unfortunately. Maybe some of these things could add a few quality years for my generation, and maybe a lot more for our children and grandchildren.

2022 in Review

First, my heart goes out to anyone who suffered hardship or lost a loved one in 2022. People still died from Covid-19 of course, not to mention other diseases, violence, and accidents. People are living, dying, and suffering horribly in war zones from Ukraine to the Middle East to Myanmar. Having said all that, for those of us living relatively sheltered lives in relatively sheltered locations like the United States, 2022 does not seem like it will rank among the best or worst of years in history.

Highlights of the Year’s Posts

These are the posts I picked each month as most frightening and/or depressing, most hopeful, and most interesting.

Most frightening and/or depressing stories:

  • JANUARY: A collapse of the Game of Thrones ice wall holding back the Thwaites glacier in Antarctica could raise average sea levels around the world by one foot, or maybe 10 feet “if it draws the surrounding glaciers with it”. The good news is that no army of zombies would pour out.
  • FEBRUARY: Philadelphia police are making an arrest in less than 40% of murders in our city, not to mention other violent crimes. Convictions of those arrested are also down. Some of this could be Covid-era dysfunction. But there is a word for this: lawlessness.
  • MARCH: What causes violence? It’s the (prohibition and war on) drugs, stupid. Or at least, partly/mostly, the drugs.
  • APRIL:  The use of small nuclear weapons is becoming more thinkable. Just a reminder that nuclear war is truly insane. Assuming we manage to avoid nuclear war, food insecurity might be our biggest near- to medium-term issue. One lesson of World War II is worries about food security played a role in the diseased minds of both Hitler and Stalin. And food prices right now are experiencing a “giant leap” unprecedented over the last couple decades. Food security, natural disasters, sea level rise, migration, and geopolitical stability all can form ugly feedback loops. And no, I couldn’t limit myself to just one depressing story this month!
  • MAY: The lab leak hypothesis is back, baby! Whether Covid-19 was or was not a lab accident, the technology for accidental or intentional release of engineered plagues has clearly arrived. And also, the world is waking up to a serious food crisis.
  • JUNE: Mass shootings are often motivated by suicidally depressed people who decide to take others with them to the grave.
  • JULY:  One way global warming is suppressing crop yields is by damaging pollen.
  • AUGUST: The fossil fuel industry intentionally used immoral, evil propaganda techniques for decades to cast doubt on climate science and make short-term profits, probably dooming us, our children, and our children’s children. Also, and because that is apparently not enough, nuclear proliferation.
  • SEPTEMBER: If humans are subject to the same natural laws as all other species on Earth, we are doomed to certain extinction by our limited genetic variety, declining fertility, and overexploitation of our habitat. So, how different are we? I can spin up a hopeful story where are evolving and overcoming our limitations through intelligence and technology, but time will tell if this is right or wrong.
  • OCTOBER: Hurricanes are hitting us (i.e., the United States: New Orleans and Puerto Rico being the examples) and we are not quite recovering back to the trend we were on before the hurricane. This seems to be happening elsewhere too, like the Philippines. This is how a system can decline and eventually collapse – it appears stable in the face of internal stressors until it is faced with an external shock, and then it doesn’t bounce back quite all the way, and each time this happens it bounces back a bit less.
  • NOVEMBER:  Asteroids could be used as a weapon.
  • DECEMBER: The U.S. legalized political corruption problem is getting worse, not better. This was one of Project Censored’s most censored stories of 2022.

Most hopeful stories:

  • JANUARY: LED lighting has gotten so efficient that it is a tossup on energy efficiency with daylight coming through a window, because no window is perfectly sealed. Windows still certainly have the psychological advantage.
  • FEBRUARY: “Green ammonia” offers some help on the energy and environmental front.
  • MARCH: There are meaningful things individuals can do to slow climate change, even as governments and industries do too little too late. For example, eat plants, limit driving and flying, and just replace consumer goods as they wear out. I’m mostly on board except that I think we need peace and stability for the long term survival of both our civilization and planetary ecosystem, and we are going to need to travel and get to know one another to give that a chance.
  • APRIL: While we are experiencing a disturbing homicide wave in U.S. cities, violent and overall crime are not necessarily at historical highs and are more or less flat. And yes, this was the most uplifting story I could come up with this month. Brave politicians could use the Ukraine emergency to talk about arms control, but if anybody is talking about that I am missing it.
  • MAY: I came up with (but I am sure I didn’t think of it first) the idea of a 21st century bill of rights. This seems to me like a political big idea somebody could run with. I’ll expand on it at some point, but quick ideas would be to clarify that the right to completely free political speech applies to human beings only and put some bounds on what it means for corporations and other legal entities, and update the 18th century idea of “unlawful search and seizure” to address the privacy/security tradeoffs of our modern world. And there’s that weird “right to bear arms” thing. Instead of arguing about what those words meant in the 18th century, we could figure out what we want them to mean now and then say it clearly. For example, we might decide that people have a right to be free of violence and protected from violence, in return for giving up any right to perpetrate violence. We could figure out if we think people have a right to a minimum standard of living, or housing, or health care, or education. And maybe clean up the voting mess?
  • JUNE: For us 80s children, Top Gun has not lost that loving feeling.
  • JULY: Kernza is a perennial grain with some promise, although yields would have to increase a lot for it to be a viable alternative to annual grains like wheat, corn and rice.
  • AUGUST: “Effective altruism” may give us some new metrics to benchmark the performance of non-profit organizations and give us some insights on dealing with existential risks (like the ones I mention above).
  • SEPTEMBER: Metformin, a diabetes drug, might be able to preemptively treat a variety of diseases colloquially referred to as “old age”.
  • OCTOBER: Gorbachev believed in the international order and in 1992 proposed a recipe for fixing it: elimination of nuclear and chemical weapons [we might want to add biological weapons today], elimination of the international arms trade, peaceful sharing and oversight of civilian nuclear technology, strong intervention in regional conflicts [he seemed to envision troops under Security Council control], promotion of food security, human rights, population control [seems a bit quaint, but maybe we would replace this with a broader concept of ecological footprint reduction today], economic assistance to poorer countries, and expansion of the Security Council to include at least India, Italy, Indonesia, Canada, Poland, Brazil, Mexico, and Egypt [maybe this list would be a bit different today but would almost certainly include Germany, Japan, Brazil, India, and Indonesia].
  • NOVEMBER: A review of Limits to Growth suggests our civilization may be on a path to stagnation rather than collapse. Or, we may be on the cusp of a fantastic science ficition future of abundance brought to us by solar energy, asteroid mining (there are those asteroids again!), and biotechnology.
  • DECEMBER: Space-based solar. This just might be the killer energy app, the last energy tech we need to come up with for awhile. Imagine what we could do with abundant, cheap, clean energy – reverse global warming, purify/desalinate as much water as we need, grow lots of food under lights in cities, power homes/businesses/factories with little or no pollution, get around in low-pollution cars/buses/trains, electrolyze as much hydrogen from water as we need for fuel cells to power aircraft and even spacecraft. Solve all these problems and we would eventually come up against other limits, of course, but this would be an enormous step forward. And space-based solar seems like much less of a fantasy than nuclear fusion or even widespread scaling up of new-generation fission designs.

Most interesting stories, that were not particularly frightening or hopeful, or perhaps were a mixture of both:

Brilliant Synthesis

Technology

The last couple years, I led off with other things and came around to a technology roundup towards the end. This year, I’ll just shake things up (yes, I’m wild and crazy like that) and lead off with technology developments during the year.

Solar energy has been a long time coming, but 2022 was a year when it really started to be at the forefront of the energy conversation and hard for the skeptics to ignore. We keep hearing that it is now the cheapest form of energy to build and put into operation. That means it is now limited by the materials needed to produce the panels, by the space needed to deploy the panels, and by the transmission and temporary storage infrastructure. Building rooftops take up a lot of space and are mostly not used for other things, so this seems like an obvious place to put the panels. The oceans of pavement we use to operate and park vehicles make up another somewhat obvious place – we can toughen the panels and drive on them, or we can put cheap roofs over the pavement and cover them with panels. Materials can be an issue because many of them are mined and sold by unsavory characters and governments, and there is clearly an environmental impact. But remember that we are trading this off against today’s coal, oil, and natural gas industry, not against some socially and ecologically blameless party. This industry intentionally lied to the public for decades and in the process did immeasurable damage to a planetary biophysical system.

Metals and minerals are also just limited. But even in hard-nosed economic terms, if solar panels are the lowest-cost option as we are hearing, they are holding their own with the costs of extracting, transporting, and burning fossil fuels. We could tax social and environmental impacts at international borders if we had the courage to do so, but even without that it is hard to imagine a system more damaging and irresponsible than the one we have been dealing with for the past century or so.

People will also say we haven’t kept the distribution infrastructure up to date, and this is true. In the United States at least, we don’t keep public infrastructure in a state of good repair. But we do create infrastructure when big business demands it, and they will demand an electric grid that can support their products when it comes to electric vehicles, devices and facilities. There may be a period of pain between when big business demands it and when the U.S. government provides it, and other countries will almost certainly outdistance us.

Longer term, as Fully Automated Luxury Communism tells it, space for solar panels will not be a problem because we will put them in, well, space. And this is not a far-future fantasy. The technology to gather the energy in space and beam it to the Earth pretty much exists now and governments and companies are seriously working on practical implementation. They swear it is safe, and even if it is not totally risk-free remember again all the death, pollution, and permanent planetary destruction the fossil fuel sociopaths have wrought.

Now, what about nuclear power? If we had really focused on it decades ago, we might not be in the climate change mess we find ourselves in now. It could still be a solution to the climate change mess in the future. But given how long it takes to bring new nuclear technology online at a large scale, and how fast solar energy appears to be scaling up and how reliable it appears to be, is it time to stop working on nuclear? I’m talking about known fission technology here. As for fusion, given that it is “always 20 years away” (no matter the year we are actually in), is it time to stop working on it and just throw all our research efforts at solar?

And materials will not be a problem either because we will produce them from asteroids and bring them to Earth, ending material shortages forever. I say, good but better to just use them to build things in space because we are running out of capacity to absorb the byproducts of the materials we already have down here. Just digging things up that were already in the ground and pumping them into the atmosphere and oceans has caused enough trouble.

By the way, once we are in space and messing around with asteroids, government and private actors will be able to divert their trajectories. It is easy to imagine scenarios where this is a great thing that actually saves all life on the planet. It is also easy to imagine scenarios where industrial accidents or intentional government actions threaten life on the planet. An international treaty and some oversight of this seems like a good idea as the messing-with-asteroids industry really starts to get going.

I don’t have my pet mini-mammoth yet, but biotechnology is continuing to gain steam. The idea of treating aging as a disease to be cured seems almost too obvious, but it seems to remove some bureaucratic obstacles that have been holding science and medicine back. Covid-19 was probably, maybe, perhaps not a lab leak. But it could have been, because the technology to make something like it, or much worse, exists in labs right now. It could be made if it has not already, and it could be leaked accidentally or intentionally, if it has not been already. And like nuclear technology, it will proliferate. Compared to nuclear technology, I think it will proliferate much faster and be much easier to hide. I have trouble envisioning any solution to this that does not involve heavy-handed surveillance.

On the positive side, biotechnology may be able to feed us when there are a lot more of us. With cellular agriculture, we can theoretically make meat or just about any kind of plant or animal tissue, and then we can eat it. We may finally be on the verge of modifying plants so they can make more efficient use of the sun’s energy, which is both exciting and scary. With a combination of abundant cheap electricity (from solar energy), abundant cheap materials, and highly efficient lighting though, we might be able to grow all the food we need in high rises without needing frankenplants.

And finally, the idea of controlling the weather with windmills is pretty fascinating. If we figure this one out, we might be able to end damage from floods, droughts, and hurricanes. But obvious Bond villain Elon Musk will also be able to use this to hold the world hostage for ONE HUNDRED TRILLION DOLLARS. That doesn’t really matter though because he is probably already planning to crash an asteroid into us anyway.

Propaganda, Social Media, and Truth

Social media is being blamed for a lot of our social ills at the moment. When we hear “social media” discussed, it seems to mean first and foremost interactive sites like Facebook, Twitter, Instagram, etc. where anyone can post a short snippet of any information they want and make it available to anybody else on the platform. Youtube also seems to fit this mold to some extent, although Youtube is a mix of personal and professionally-produced content. Then, underlying all this are Google search and other algorithms or “search” engines which are searching both for content to show individuals and individuals to show content. There are bloggers using WordPress and a million other tools and sites trying to get their content out, usually not all that widely if my personal experience is any indication (to the 5 or 6 people worldwide who read this blog regularly?) Then there is the huge ecosystem of Amazon and all the other sites trying to sell us stuff. Then there is professional journalistic media and traditional publishing companies trying to have their say (and sell us stuff), and finally there is some sense of the broader internet underlying all this.

Beyond trying to sell us stuff, corporations and non-profit entities are trying to manipulate all these communication channels to get their messages into our heads. This is propaganda, with the main goal being to sell us stuff and a secondary goal being to create awareness and positive images of their brands so they can keep selling us stuff. Also so people won’t complain to politicians about whatever the corporations are doing and risk those politicians meddling in the system in ways that are averse to corporate profits. At the same time, these companies and special interest groups are paying off the politicians to support their interests behind the scenes. This works out well for them (the corporations, special interests and politicians).

Finally we have the U.S. government and governments around the world trying to influence public opinion, occasionally by providing accurate information, sometimes outright lies, and often something in between.

All this is competing for our “attention”. Personally, I strongly prefer having more information to less, and I do not want to see regulation aimed at reducing the amount of information available to me. I believe, perhaps naively, that I have some ability to distinguish truth from falsehood, fact from opinion, and objective/honest communication from dishonest attempts to influence me. Regulation to protect children might be an exception to this – if social media sites are facilitating bullying and leading to mental health problems and even suicides, that is worth dealing with.

“Great Power Competition”, the “International Order”, and the United Nations

A major world leader of our time died in 2022. Okay, two world leaders if you really want to count Queen Victoria, but I am talking about Mikhail Gorbachev. To me, he represents a moment when optimism and visionary leadership had a chance to flower to the benefit of our civilization. He had a vision of long-term peace and stability, with powerful nation-states ceding some of their power to some form of world government. The basic vision was that no nation-state, no matter how powerful, would be able to succeed through violent means if it was opposed by all other nation-states acting together. With the threat of catastrophic war mostly behind us, humanity could have focused on solving all the other thorny problems, from food to energy to pollution to inequality. This was a beautiful vision, but unfortunately its moment passed us by, and we are back to the old cynical idea of coalitions of “great powers” arrayed against each other.

With the threat of catastrophic violence hanging over us, we are not focused on solving those other problems. The United Nations was supposed to at least be the seed of that new order that would usher in long-term peace and prosperity for our species. To be sure, the United Nations has accomplished a lot when it comes to human rights, science, agriculture, refugees, and other areas. It has also been a place where all the not-so-great powers of the world can band together and make their voices somewhat heard. But the Security Council was supposed to be the One Ring to Rule Them All and make “great power competition” obsolete. This has failed utterly, with the Security Council considered all but irrelevant at this point. Not only is “great power competition” ascendant, we seem to be proud of ourselves for bringing it back. If there is a devil, he must truly love “great power competition”.

With the threat of catastrophic violence hanging over us, we have failed utterly to solve other existential problems such as food security, global warming, sea level rise, ever-growing concentration of wealth, and the specter of a Captain Trips extinction plague whether of natural or manmade origin.

Resilience. Despite taking a gut punch, at the end of 2022 it feels as though our planetary civilization weathered the storm of Covid-19 and has more or less rebounded to something like the trend it would have been on. This is the textbook definition of resilience, and something to feel good about. If we get some time in between gut punches, we at least have an opportunity to work on our other problems while also preparing for the next gut punch. If we don’t make progress, maybe we can at least reach a state of stagnation rather than a self-actuated collapse. Can a civilization be resilient and stagnant at the same time? Maybe this is where we find ourselves, at least in the near term.

Happy 2023!

U.S. life span inequality

We hear a lot about health and life expectancy differences between ethnic groups and income levels in the U.S. This article shows those same numbers by county. Not too surprisingly, Appalachia and the southeast have some of the lowest average life expectancies. Heart disease and drug overdoses are major reasons why. The most shocking numbers though are from heavily Native American areas.

The article prescribes more exercise, healthier food, blood pressure and cholesterol control, and lower health care costs. Sounds good. In my opinion, high cost is certainly an issue, but it is really a proxy for access. We need a health care system that provides access to everyone, at least starting with basic preventive care. This is not particularly high tech. Let’s do it.

September 2022 in Review

Most frightening and/or depressing story: If humans are subject to the same natural laws as all other species on Earth, we are doomed to certain extinction by our limited genetic variety, declining fertility, and overexploitation of our habitat. So, how different are we? I can spin up a hopeful story where are evolving and overcoming our limitations through intelligence and technology, but time will tell if this is right or wrong.

Most hopeful story: Metformin, a diabetes drug, might be able to preemptively treat a variety of diseases colloquially referred to as “old age”.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: Biotechnology might be on the cusp of producing plants that can make more efficient use of the sun’s energy. This could be good for the food supply, and bad if the damn things escape into the woods. And in tangentially related news, yields of salad vegetables can actually be higher in urban areas than on conventional farms. Those coastal elites and their fancy salads, why can’t they just live on simple basic grains like Doritos the way the rest of us do?

metformin and longevity

This article says billionaires are “racing” to invest in longevity treatments. Top candidates attracting funding include various gene therapies, drugs, stem cells, and old people consuming the blood of children (seriously, this is real but presumably the children are fine). This article argues a known drug called metformin deserves more attention.

lobsters are not immortal, or at least only sort of

From McGill University:

So why do we stop growing, while lobsters don’t? The cells that make up our body are constantly making new cells by dividing. A biological technicality causes us to lose a bit of DNA at the ends of our chromosomes (structures made up of DNA and proteins) after each replication. DNA contains the blueprint for our lives, so in order to make sure we aren’t losing crucial information during these divisions, the long molecules of DNA are protected by shorter segments of DNA at their ends called “telomeres.” An analogy would be the plastic tips on a shoelace that prevent it from unraveling. When a cell multiplies, the only part of the chromosome that is lost is a piece of the telomeres. But as we age, our telomeres get shorter, until they reach a critical point where the cell can no longer replicate without damage to its essential DNA. When this occurs, the cell becomes inactive or dies. Shortening of telomeres is linked to senescence and increased risk of disease. Other contributors to aging include oxidative stress (hence the appeal of antioxidants).

Lobsters have a perpetual supply of telomerase – the enzyme that can restore telomeres, helping cells avoid that fateful end. Humans also have telomerase, just not enough to overcome the constant shortening of telomeres. In fact, telomerase is often found in cancer cells, giving tumours a survival advantage.

Unfortunately for our pal Larry, a large supply of telomerase can be a double-edged sword. Lobsters are still more likely to die with age because their hard-shell exoskeleton moults and has to be regrown. This requires reams of energy, eventually too much. As a result, common causes of death for lobsters are exhaustion, immobility, and shell disease, although the leading cause is still predation.

McGill

The article goes on to say that there are actually some jellyfish that are biologically immortal, meaning they do not age or ever die of old age, although they can be killed.

Given an infinite span of time, the odds of a “biologically immortal” organism being killed would seem to be 100%. So this does not sound like immortality to me in a colloquial sense, But figure out this mystery and come up with a drug to restore our telomeres without causing cancer, and we could live for a long, long time if we are careful. Would our brains hold up more than a century or so?

Interestingly, and this is a frequent point of conversation my son likes to bring up, the Norse gods are “biologically immortal” because they do not age but they can be killed (sorry, Thor fans). But the Greek/Roman gods are truly indestructible. I recall one story where Zeus was cut up into little pieces and put into a bag by another one of the gods. Eventually, somebody let him out and the pieces just assembled themselves together again and he continued being Zeus.

U.S. life expectancy down

From a not-yet-peer-reviewed study:

An April 2022 study conducted by researchers from the Virginia Commonwealth University, University of Colorado Boulder, and the Urban Institute, analyzed provisional government statistics that showed that overall U.S. life expectancy is now 76.6 years — the lowest figure in 25 years.

This drop comes after life expectancy plummeted from 78.86 years in 2019 to 76.99 years in 2020, according to the researchers. The net loss of 2.26 years was the biggest one year fall since at least World War II, NPR reported

It noted that even though the Black and Latino populations had bigger drops in life expectancy in 2020, this did not continue into 2021. Life expectancy among Latinos did not change significantly in 2021, and marginally went up in the Black population. In contrast, the life expectancy of white people, mostly men, declined slightly.

Snopes

We have heard about “deaths of despair” – suicide, drugs and alcohol – increasing among white men, so maybe this was the indirect effects of the pandemic coming home to roost.

Trends in life expectancy are a useful metric because they are a pretty objective measure of overall human wellbeing in society – encompassing some mix of physical and mental health, work life balance, child welfare, nutrition, environmental conditions like air quality, car accidents and other accidental deaths, etc. But individual life span is a very personal thing, as I try to convince my parents in their 70s. The fact that you are close to or over the average means you have already survived many things that are causing some people to die young and pull down the average.

2021: Year in Review

As per usual, I’ll list out and link to the stories I chose as the most frightening, most hopeful, and most interesting each month in 2021. Then I’ll see if I have anything smart to say about how it all fits together.

Survey of the Year’s Stories and Themes

Most frightening and/or depressing stories:

  • JANUARY: A China-Taiwan military conflict is a potential start-of-World-War-III scenario. This could happen today, or this year, or never. Let’s hope for the latter. This is a near-term existential risk, but I have to break my own “rule of one” and give honorable mention to two longer-term scary things: crashing sperm counts and the climate change/fascism/genocide nexus.
  • FEBRUARY: For people who just don’t care that much about plants and animals, the elevator pitch on climate change is it is coming for our houses and it is coming for our food and water.
  • MARCH: In the U.S. upper Midwest (I don’t know if this region is better or worse than the country as a whole, or why they picked it), electric blackouts average 92 minutes per year, versus 4 minutes per year in Japan.
  • APRIL: One of the National Intelligence Council’s scenarios for 2040 involves “far-reaching changes designed to address climate change, resource depletion, and poverty following a global food catastrophe caused by climate events and environmental degradation”.
  • MAY: The Colorado River basin is drying out.
  • JUNE: For every 2 people who died of Covid-19 in the U.S. about 1 additional person died of indirect effects, such as our lack of a functioning health care system and safe streets compared to virtually all our peer countries.
  • JULY: The western-U.S. megadrought looks like it is settling in for the long haul.
  • AUGUST: The U.S. is not prepared for megadisasters. Pandemics, just to cite one example. War and climate change tipping points, just to cite two others. Solutions or at least risk mitigation measures exist, such as getting a health care system, joining the worldwide effort to deal with carbon emissions, and as for war, how about just try to avoid it?
  • SEPTEMBER: The most frightening climate change tipping points may not be the ones we hear the most about in the media (at least in my case, I was most aware of melting ice sheets in Greenland and Antarctica, collapse of ocean circulation patterns). The most damaging may be melting permafrost on land and methane hydrates underwater, both of which contain enormous amounts of methane which could set off a catastrophic and unstoppable feedback loop if released in large quantities.
  • OCTOBER: The technology (sometimes called “gain of function“) to make something like Covid-19 or something much worse in a laboratory clearly exists right now, and barriers to doing that are much lower than other types of weapons. Also, because I just couldn’t choose this month, asteroids can sneak up on us.
  • NOVEMBER: Freakonomics podcast explained that there is a strong connection between cars and violence in the United States. Because cars kill and injure people on a massive scale, they led to an expansion of police power. Police and ordinary citizens started coming into contact much more often than they had. We have no national ID system so the poor and disadvantaged often have no ID when they get stopped. Everyone has guns and everyone is jumpy. Known solutions (safe street design) and near term solutions (computer-controlled vehicles?) exist, but are we going to pursue them as a society? I guess I am feeling frightened and/or depressed today, hence my choice of category here.
  • DECEMBER: Mass migration driven by climate change-triggered disasters could be the emerging big issue for 2022 and beyond. Geopolitical instability is a likely result, not to mention enormous human suffering.

Most hopeful stories:

  • JANUARY: Computer modeling, done well, can inform decisions better than data analysis alone. An obvious statement? Well, maybe to some but it is disputed every day by others, especially staff at some government regulatory agencies I interact with.
  • FEBRUARY: It is possible that mRNA technology could cure or prevent herpes, malaria, flu, sickle cell anemia, cancer, HIV, Zika and Ebola (and obviously coronavirus). With flu and coronavirus, it may become possible to design a single shot that would protect against thousands of strains. It could also be used for nefarious purposes, and to protect against that are ideas about what a biological threat surveillance system could look like.
  • MARCH: I officially released my infrastructure plan for America, a few weeks before Joe Biden released his. None of the Sunday morning talk shows has called me to discuss so far. Unfortunately, I do not have the resources of the U.S. Treasury or Federal Reserve available to me. Of course, neither does he unless he can convince Congress to go along with at least some portion of his plans. Looking at his proposal, I think he is proposing to direct the fire hoses at the right fires (children, education, research, water, the electric grid and electric vehicles, maintenance of highways and roads, housing, and ecosystems. There is still no real planning involved, because planning needs to be done in between crises and it never is. Still, I think it is a good proposal that will pay off economically while helping real people, and I hope a substantial portion of it survives.
  • APRIL: Giant tortoises reach a state of “negligible senescense” where they simply don’t age for a long time. Humans are distant relatives of giant tortoises, so maybe we can aspire to this some day. They are not invulnerable to injury and disease.
  • MAY: An effective vaccine for malaria may be on the way. Malaria kills more children in Africa every year than Covid-19 killed people of all ages in Africa during the worst year of the pandemic. And malaria has been killing children every year for centuries and will continue long after Covid-19 is gone unless something is done.
  • JUNE: Masks, ventilation, and filtration work pretty well to prevent Covid transmission in schools. We should learn something from this and start designing much healthier schools and offices going forward. Design good ventilation and filtration into all buildings with lots of people in them. We will be healthier all the time and readier for the next pandemic. Then masks can be slapped on as a last layer of defense. Enough with the plexiglass, it’s just stupid and it’s time for it to go.
  • JULY: A new Lyme disease vaccine may be on the horizon (if you’re a human – if you are a dog, talk to your owner about getting the approved vaccine today.) I admit, I had to stretch a bit to find a positive story this month.
  • AUGUST: The Nordic welfare model works by providing excellent benefits to the middle class, which builds the public and political support to collect sufficient taxes to provide the benefits, and so on in a virtuous cycle. This is not a hopeful story for the U.S., where wealthy and powerful interests easily break the cycle with anti-tax propaganda, which ensure benefits are underfunded, inadequate, available only to the poor, and resented by middle class tax payers.
  • SEPTEMBER: Space-based solar power could finally be in our realistic near-term future. I would probably put this in the “interesting” rather than “hopeful” category most months, but I really struggled to come up with a hopeful story this month. I am at least a tiny bit hopeful this could be the “killer app” that gets humanity over the “dirty and scarce” energy hump once and for all, and lets us move on to the next layer of problems.
  • OCTOBER: The situation with fish and overfishing is actually much better than I thought.
  • NOVEMBER: Urban areas may have some ecological value after all.
  • DECEMBER: Covid-19 seems to be “disappearing” in Japan, or at least was before the Omicron wave. Maybe lessons could be learned. It seems possible that East Asian people have at least some genetic defenses over what other ethnic groups have, but I would put my money on tight border screening and an excellent public health care system. Okay, now I’m starting to feel a bit depressed again, sitting here in the U.S. where we can’t have these nice things thanks to our ignorant politicians.

Most interesting stories, that were not particularly frightening or hopeful, or perhaps were a mixture of both:

  • JANUARY: There have been fabulous advances in note taking techniques! Well, not really, but there are some time honored techniques out there that could be new and beneficial for many people to learn, and I think this is an underappreciated productivity and innovation skill that could benefit people in a lot of areas, not just students.
  • FEBRUARY: At least one serious scientist is arguing that Oumuamua was only the tip of an iceberg of extraterrestrial objects we should expect to see going forward.
  • MARCH: One study says 1-2 days per week is a sweet spot for working from home in terms of a positive economic contribution at the national scale. I think it is about right psychologically for many people too. However, this was a very theoretical simulation, and other studies attempting to measure this at the individual or firm scale have come up with a 20-50% loss in productivity. I think the jury is still out on this one, but I know from personal experience that people need to interact and communicate regularly for teams to be productive, and some people require more supervision than others, and I don’t think technology is a perfect substitute for doing these things in person so far.
  • APRIL: Hydrogen fuel cells may finally be arriving. Not so much in the U.S., where we can’t have nice things.
  • MAY: I learned about Lawrence Kohlberg, who had some ideas on the use of moral dilemmas in education.
  • JUNE: The big U.S. government UFO report was a dud. But what’s interesting about it is that we have all quietly seemed to have accepted that something is going on, even if we have no idea what it is, and this is new.
  • JULY: “Cliodynamics” is an attempt at a structured, evidence-based way to test hypotheses about history.
  • AUGUST: Ectogenesis is an idea for colonizing other planets that involves freezing embryos and putting them on a spaceship along with robots to thaw them out and raise them. Fungi could also be very useful in space, providing food, medicine, and building materials.
  • SEPTEMBER: Philip K. Dick was not only a prolific science fiction author, he also developed a comprehensive theory of religion which could possibly even be the right one. Also, possibly related but not really, if there are aliens out there they might live in creepy colonies or super-organisms like ants or termites.
  • OCTOBER: I thought about how to accelerate scientific progress: “[F]irst a round of automated numerical/computational experiments on a huge number of permutations, then a round of automated physical experiments on a subset of promising alternatives, then rounds of human-guided and/or human-performed experiments on additional subsets until you hone in on a new solution… [C]ommit resources and brains to making additional passes through the dustbin of rejected results periodically…” and finally “educating the next generation of brains now so they are online 20 years from now when you need them to take over.” Easy, right?
  • NOVEMBER: Peter Turchin continues his project to empirically test history. In this article, he says the evidence points to innovation in military technologies being driven by “world population size, connectivity between geographical areas of innovation and adoption, and critical enabling technological advances, such as iron metallurgy and horse riding“. What does not drive innovation? “state-level factors such as polity population, territorial size, or governance sophistication“. As far as the technologies coming down the pike in 2022, one “horizon scan” has identified “satellite megaconstellations, deep sea mining, floating photovoltaics, long-distance wireless energy, and ammonia as a fuel source”.
  • DECEMBER: Time reminded us of all the industries Elon Musk has disrupted so far: human-controlled, internal-combustion-fueled automobiles; spaceflight; infrastructure construction (I don’t know that he has really achieved any paradigm shifts here, but not for lack of trying), “artificial intelligence, neurotechnology, payment systems and cryptocurrency.” I’m not sure I follow a couple of these, but I think they missed satellites.

Continuing Signs of U.S. Relative Decline

Signs of U.S. decline relative to our peer group of advanced nations are all around us. I don’t know that we are in absolute decline, but I think we are now below average among the most advanced countries in the world. We are not investing in the infrastructure needed in a modern economy just to reduce friction and let the economy function. The annual length of electric blackouts in the U.S. (hours) compared to leading peers like Japan (minutes) is just one telling indicator. In March, I looked at the Build Back Better proposal and concluded that it was more like directing a firehose of money at a range of problems than an actual plan, but I hoped at least some of it would happen. My rather low but not zero expectations were met, as some limited funding was provided for “hard infrastructure” and energy/emissions projects, but little or nothing (so far, as I write this) to address our systemic failures in health care, child care, or education. The crazy violence on our streets, both gun-related and motor vehicle-related, is another indicator. Known solutions to all these problems exist and are being implemented to various extents by peer countries. Meanwhile our toxic politics and general ignorance continue to hold us back. Biden really gave it his best shot – but if this is our “once in a generation” attempt, we are headed down a road where we will no longer qualify as a member of the pack of elite countries, let alone its leader.

The Climate Change, Drought, Food, Natural Disaster, Migration and Geopolitical Instability Nexus

2021 was a pretty bad year for storms, fires, floods, and droughts. All these things affect our homes, our infrastructure, our food supply, and our water supply. Drought in particular can trigger mass migration. Mass migration can be a disaster for human rights and human dignity in and of itself, and managing it effectively is difficult even for well-intentioned governments. But an insidious related problem is that migration pressure can tend to fuel right wing populist and racist political movements. We see this happening all over the world, and the situation seems likely to get worse.

Tipping Points and other Really Bad Things We Aren’t Prepared For

We can be thankful that nothing really big and new and bad happened in 2021. My apologies to anyone reading this who lost someone or had a tough year. Of course, plenty of bad things happened to good people, and plenty of bad things happened on a regional or local scale. But while Covid-19 ground on and plenty of local and regional-scale natural disasters and conflicts occurred, there were no new planetary-scale disasters. This is good because humanity has had enough trouble dealing with Covid-19, and another major disaster hitting at the same time could be the one that brings our civilization to the breaking point.

So we have a trend of food insecurity and migration pressure creeping up on us over time, and we are not handling it well even given time to do so. Maybe we can hope that some adjustments will be made there to get the world on a sustainable track. Even if we do that, there are some really bad things that could happen suddenly. Catastrophic war is an obvious one. A truly catastrophic pandemic is another (as opposed to the moderately disastrous pandemic we have just gone through.) Creeping loss of human fertility is one that is not getting much attention, but this seems like an existential risk if it were to cross some threshold where suddenly the global population starts to drop quickly and we can’t do anything about it. Asteroids were one thing I really thought we didn’t have to worry much about on the time scale of any human alive today, but I may have been wrong about that. And finally, the most horrifying risk to me in the list above is the idea of an accelerating, runaway feedback loop of methane release from thawing permafrost or underwater methane hydrates.

We are almost certainly not managing these risks. These risks are probably not 100% avoidable, but since they are existential we should be actively working to minimize the chance of them happening, preparing to respond in real time, and preparing to recover afterward if they happen. Covid-19 was a dress rehearsal for dealing with a big global risk event, and humanity mostly failed to prepare or respond effectively. We are lucky it was one we should be able to recover from as long as we get some time before the next body blow. We not only need to prepare for much, much worse events that could happen, we need to match our preparations to the likelihood of more than one of them happening at the same time or in quick succession.

Technological Progress

Enough doom and gloom. We humans are here, alive, and many of us are physically comfortable and have much more leisure time than our ancestors. Our social, economic, and technological systems seem to be muddling through from day to day for the time being. We have intelligence, science, creativity, and problem solving abilities available to us if we choose to make use of them. Let’s see what’s going on with technology.

Biotechnology: The new mRNA technology accelerated by the pandemic opens up potential cures for a range of diseases. We need an effective biological surveillance system akin to nuclear weapons inspections (which we also need) to make sure it is not misused (oops, doom and gloom trying to creep in, but there are some ideas for this.) We have vaccines on the horizon for diseases that have been plaguing us for decades or longer, like malaria and Lyme disease. Malaria kills more children worldwide, year in and year out, than coronavirus has killed per year at its peak.

Promising energy technologies: Space based solar power may finally be getting closer to reality. Ditto for hydrogen fuel cells in vehicles, although not particularly in the U.S. (I’m not sure this is preferable to electric vehicles for everyday transportation, but it seems like a cleaner alternative to diesel and jet fuel when large amounts of power are needed in trucking, construction, and aviation, for example.)

Other technologies: We are actually using technology to catch fish in more sustainable ways, and to grow fish on farms in more sustainable ways. We are getting better at looking for extraterrestrial objects, and the more we look, the more of them we expect to see (this one is exciting and scary at the same time). We are putting satellites in orbit on an unprecedented scale. We have computers, robots, artificial intelligence of a sort, and approaches to use them to potentially accelerate scientific advancements going forward.

The State of Earth’s Ecosystems

The state and trends of the Earth’s ecosystems continue to be concerning. Climate change continues to churn through the public consciousness and our political systems, and painful as the process is I think our civilization is slowly coming to a consensus that something is happening and something needs to be done about it (decades after we should have been able to do this based on the evidence and knowledge available.) When it comes to our ecosystems, however, I think we are in the very early stages of this process. This is something I would like to focus on in this blog in the coming year. My work and family life are busy, and I have decided to take on an additional challenge of becoming a student again for the first time in the 21st century, but somehow I will persevere. If you are reading this shortly after I write it in January 2022, here’s to good luck and prosperity in the new year!

April 2021 in Review

Most frightening and/or depressing story: One of the National Intelligence Council’s scenarios for 2040 involves “far-reaching changes designed to address climate change, resource depletion, and poverty following a global food catastrophe caused by climate events and environmental degradation”.

Most hopeful story: Giant tortoises reach a state of “negligible senescense” where they simply don’t age for a long time. Humans are distant relatives of giant tortoises, so maybe we can aspire to this some day. They are not invulnerable to injury and disease.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: Hydrogen fuel cells may finally be arriving. Not so much in the U.S., where we can’t have nice things.