Tag Archives: longevity

a new book about longevity research

We should try to be more like the Galapagos tortoises, which achieve a state of “negligible senescence” and stay there for many decades. This is according to a new book called Ageless: The New Science of Getting Older without Getting Old. From the New York Times (which, just as a reminder, I will never subscribe to until/unless they apologize for lying to me about weapons of mass destruction):

This is, in fact, “what we should aim for,” Steele says: “a risk of death, disability, frailty and illness which doesn’t depend on how long ago you were born.” In precise and sometimes dense detail he lays out the means by which science could effectively eliminate human aging. These approaches fall into four categories: “removing bad things that accumulate,” “renewing things which are broken or lost,” “repairing things which are damaged or out of kilter” and “reprogramming our biology to slow or reverse aging.”

New York Times

Overpopulation and funding pensions might become an issue in such a world. Then again, if we are really losing our ability to reproduce through natural means, we might need to become a living dead species just to be able to stick around for awhile.

the “best” health advice from 2019

The Week has cherry picked a few studies from 2019 as best. Although they did pick ones with large sample sizes, what would be “best” to me would be some kind of meta-analysis of all studies published and what they said on balance, with some kind of grading for quality and communication of the uncertainty involved. That would be awesome journalism, but I imagine it would be expensive. The great news is that if you add up all the percentages that doing this and that can reduce your chances of death, you can live forever! Anyway, here is my quick summary:

  • Exercise, fruits, vegetables, and whole grains just never go out of style. More whole foods (the thing, not the chain) and less processed foods in general seem to be a very good idea. Seriously, just orient your life style around these things and it is very unlikely the scientific consensus will change some day and tell you it was a bad idea.
  • Napping is good for you – this particular study says “five minutes to an hour once or twice a week”. I’m not surprised that rest is good for the heart, but I thought there was an emerging consensus that maintaining a consistent schedule on all days was good, and this seems to contradict that a bit.
  • Parents are stressed out while kids are young, then ultimately glad they had the kids later in life. This doesn’t surprise me since I am living through the stressed out part, but I do find it helpful to put myself in my future self’s shoes and ask if I would regret having children. In fact, my wife and I did that when we made the decision to have children, and the answer was and is no, we have no regrets. The distinction between happiness in the moment and overall life satisfaction also comes to mind.
  • Aspirin and ibuprofen seem to help your heart, but also raise your risk of internal bleeding. It’s probably best not to self-medicate.
  • Smoking and getting hit on the head, even gently, are not good for you.

June 2019 in Review

Most frightening and/or depressing story:

  • The world economy appears to be slowing, even though U.S. GDP is growing as the result of the post-2007 recovery finally taking hold, juiced by a heavy dose of pro-cyclical government spending. The worry is that if and when there is eventually a shock to the system, there will be little room for either fiscal or monetary policy to respond. Personally, the partisan in me is thinking any time before November 2020 is as good a time for any for a recession to hit the U.S. I am a couple decades from retirement, and picturing that bumper sticker “Lord, Just Give Me One More Bubble”. Of course, this is selfish thinking when there are many people close to retirement and many families struggling to get by out there. And short-term GDP growth is not the only metric. The U.S. is falling behind its developed peers on a wide range of metrics that matter to people lives, including infrastructure, health care costs and outcomes, life expectancy, maternal and infant mortality, addiction, suicide, poverty, and hunger. And it’s not just that we are no longer in the lead on these metrics, we are below average and falling. Which is why I am leading the charge to Make America Average Again!

Most hopeful story:

  • There have been a number of serious proposals and plans for disarmament and world peace in the past, even since World War II. We have just forgotten about them or never heard of them.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both:

  • In technology news, Elon Musk is planning to launch thousands of satellites. And I learned a new acronym, DARQ: “distributed ledger technology (DLT), artificial intelligence (AI), extended reality (XR) and quantum computing”. And in urban planning news, I am sick and tired of the Dutch just doing everything right.

 

what’s new with longevity treatments

This article in The Week mentions a few things.

Humans grow fewer blood vessels in their muscles with age, which is believed to result in the gradual breakdown of vital organs. The same pattern exists in mice. In 2018, Harvard researchers fed mice a chemical to manipulate the gene associated with blood vessel growth and found that old mice subsequently were able to run on a treadmill 56 percent longer. While that work continues, biohackers are transfixed by nootropics — “smart drugs,” amino acids, and other supplements that purportedly boost cognitive abilities and prevent brain aging.

Mainstream scientists and doctors are still saying nay. I don’t know but exercising to keep the oxygen level up seems like a good idea.

2018 in Review

Most frightening and/or depressing stories:

  • JANUARY: Cape Town, South Africa looked to be in imminent danger of running out of water. They got lucky, but the question is whether this was a case of serious mismanagement or an early warning sign of water supply risk due to climate change. Probably a case of serious mismanagement of the water supply while ignoring the added risk due to climate change. Longer term, there are serious concerns about snowpack-dependent water supplies serving large urban populations in Asia and western North America.
  • FEBRUARY: Cape Town will probably not be the last major city to run out of water. The other cities at risk mentioned in this article include Sao Paulo, Bangalore, Beijing, Cairo, Jakarta, Moscow, Istanbul, Mexico City, London, Tokyo, and Miami.
  • MARCH: One reason propaganda works is that even knowledgeable people are more likely to believe a statement the more often it is repeated.
  • APRIL: That big California earthquake is still coming.
  • MAY: The idea of a soft landing where absolute dematerialization of the economy reduces our ecological footprint and sidesteps the consequences of climate change through innovation without serious pain may be wishful thinking.
  • JUNE: The Trump administration is proposing to subsidize coal-burning power plants. Meanwhile the long-term economic damage expected from climate change appears to be substantial. For one thing, Hurricanes are slowing down, which  means they can do more damage in any one place. The rate of melting in Antarctic ice sheets is accelerating.
  • JULY: The UN is warning as many as 10 million people in Yemen could face starvation by the end of 2018 due to the military action by Saudi Arabia and the U.S. The U.S. military is involved in combat in at least 8 African countries. And Trump apparently wants to invade Venezuela.
  • AUGUST: Noam Chomsky doesn’t love Trump, but points out that climate change and/or nuclear weapons are still existential threats and that more mainstream leaders and media outlets have failed just as miserably to address them as Trump has. In related news, the climate may be headed for a catastrophic tipping point and while attention is mostly elsewhere, a fundamentalist takeover of Pakistan’s nuclear arsenal is still one of the more serious risks out there.
  • SEPTEMBER: A huge earthquake in the Pacific Northwest could be by far the worst natural disaster ever seen.
  • OCTOBER: The Trump administration has slashed funding to help the U.S. prepare for the next pandemic.
  • NOVEMBER: About half a million people have been killed in Iraq, Afghanistan, and Pakistan since the U.S. invasions starting in 2001. This includes only people killed directly by violence, not disease, hunger, thirst, etc.
  • DECEMBER: Climate change is just bad, and the experts seem to keep revising their estimates from bad to worse. The Fourth National Climate Assessment produced by the U.S. government is not an uplifting publication. In addition to the impacts of droughts, storms, and fires, it casts some doubt on the long-term security of the food supply. An article in Nature was also not uplifting, arguing that climate change is happening faster than expected due to a combination of manmade and natural trends.

Climate change, nuclear weapons, and pandemics. If I go back and look at last year’s post, this list of existential threats is going to be pretty much the same. Add to this the depressing grind of permanent war which magnifies these risks and diverts resources that could be used to deal with them. True, we could say that we got through 2018 without a nuclear detonation, pandemic, or ecological collapse, and under the circumstances we should sit back, count our blessings, and wait for better leadership. And while our leadership is particularly inept at the moment, I think Noam Chomsky has a point that political administration after political administration has failed to solve these problems and this seems unlikely to improve. The earthquake risk is particularly troublesome. Think about the shock we felt over the inept response to Katrina, and now think about how essentially the same thing happened in Puerto Rico, we are not really dealing with it in an acceptable way, and the public and news media have essentially just shrugged it off and moved on. If the hurricanes, floods, fires and droughts just keep hitting harder and more often, and we don’t fully respond to one before the next hits, it could mean a slow downward spiral. And if that means we gradually lose our ability to bounce back fully from small and medium size disasters, a truly huge disaster like an epic earthquake on the west coast might be the one that pushes our society to a breaking point.

Most hopeful stories:

I believe our children are our future…ya ya blahda blahda. It’s a huge cliche, and yet to be hopeful about our world I have to have some hope that future generations can be better system thinkers and problem solvers and ethical actors than recent generations have been. Because despite identifying problems and even potential solutions we are consistently failing to make choices as a society that could divert us from the current failure path. And so I highlighted a few stories above about ideas for better preparing future generations, ranging from traditional school subjects like reading and music, to more innovative ones like meditation and general system theory, and just maybe we should be open to the idea that the right amount of the right drugs can help.

Fossil fuels just might be on their way out, as alternatives start to become economical and public outrage slowly, almost imperceptibly continues to build.

There is real progress in the fight against disease, which alleviates enormous quantities of human suffering. I mention AIDS, diabetes, and Alzheimer’s disease above. We can be happy about that, of course. There are ideas about how to grow more food, which is going to be necessary to avoid enormous quantities of human suffering. Lest anyone think otherwise, my position is that we desperately need to reduce our ecological footprint, but human life is precious and nobody deserves to suffer illness or hunger.

Good street design that lets people get around using mostly their own muscle power. It might not be sexy, but it is one of the keys to physical and mental health, clean air and water, biodiversity, social and economic vibrancy in our cities. Come to think of it, I take that back, it can be sexy if done well.

Good street design and general systems theory – proof that solutions exist and we just don’t recognize or make use of them. Here’s where I want to insert a positive sentence about how 2019 is the year this all changes for the better. Well, sorry, you’ll have to find someone less cynical than me, and/or with much better powers of communication and persuasion than me to get the ball rolling. On the off chance I have persuaded you, and you have communication and/or persuasion super powers, let me know.

Most interesting stories, that were not particularly frightening or hopeful, or perhaps were a mixture of both:

Whatever else happens, technology and accumulation of human knowledge in general march on, of course. Computer, robotics, and surveillence technology march on. The human move into space is much slower and painful than many would have predicted half a century ago, and yet it is proceeding.

I’ll never drop the waterless sanitation thing, no matter how much others make fun of me. It’s going to happen, eventually. I don’t know whether we will colonize Mars or stop defecating in our water supply first, but both will happen.

The gene drive thing is really wild the more I think about it. This means we now have the ability to identify a species or group of species we don’t want to exist, then cause it not to exist in relatively short order. This seems like it could be terrifying in the wrong hands, doesn’t it? I’m not even sure I buy into the idea that rats and mosquitoes have no positive ecological functions at all. Aren’t there bats and birds that rely on mosquitoes as a food source? Okay, I’m really not sure what redeeming features rats have, although I did read a few years ago that in a serious food crunch farming rats would be a much more efficient way of turning very marginal materials into edible protein than chicken.

The universe in a bottle thing is mind blowing if you spend too much time thinking about it. It could just be bottles all the way down. It’s best not to spend too much time thinking about it.

That’s it, Happy 2019!

ultrasound treatment for dementia

This article in New Atlas (which I don’t know anything about) reports on an ultrasound-based treatment for dementia and Alzheimer’s that has been successful in mice and is moving to human trials next year.

The ultrasound treatment was first developed back in 2015 at the University of Queensland. The initial research was working to find a way to use ultrasound to temporarily open the blood-brain barrier with the goal of helping dementia-battling antibodies better reach their target in the brain. However, early experiments with mice surprisingly revealed the targeted ultrasound waves worked to clear toxic amyloid protein plaques from the brain without any additional therapeutic drugs.

“The ultrasound waves oscillate tremendously quickly, activating microglial cells that digest and remove the amyloid plaques that destroy brain synapses,” explained Jürgen Götz, one of the researchers on the project back in 2015. “The word ‘breakthrough’ is often mis-used, but in this case I think this really does fundamentally change our understanding of how to treat this disease, and I foresee a great future for this approach.”

23 is not enough for me

This article in Wired explains how there is a lot more to sequencing the whole genome than just 23 genes. The cost of full sequencing has dropped to $1000, which is considered an enormous breakthrough, and it is expected to continue to fall. One company is even offering a $200 black Friday special even though they admit it is a loss leader.

Today, slightly more than a million people have had their whole genomes sequenced. Compare that to the 17 million estimated to have had their DNA analyzed with direct-to-consumer tests sold by 23andMe and Ancestry. They use a technology called genotyping, which takes about a million snapshots of a person’s genome. That might sound like a lot, but it’s really less than 1 percent of the full picture. Genotyping targets short strings of DNA that scientists already know have a strong association with a given trait. So say, for example, scientists discover a new gene that increases your risk of developing brain cancer. If that gene is not one that 23andMe looks at (because how would it know to look if the gene hasn’t been discovered yet), then you’d have to get tested all over again to learn more about your brain cancer risk. Whole genome data on the other hand, once you have it, can be queried with computer algorithms whenever a new genetic discovery gets made.

Here’s a good example of just how much more info is in a whole genome: Earlier this year, 23andMe got FDA approval to give consumers information about their BRCA1 and BRCA2 genes. More than 1,000 mutations in these genes are known to increase women’s chances of breast and ovarian cancers by as much as 75 and 50 percent, respectively. 23andMe’s test picks up the three BRCA mutations most commonly found in individuals of Ashkenazi Jewish descent, and geneticists have voiced concern that the results could leave people with a false sense of security. Veritas’ tests, on the other hand, scan for all of them and, according to the company, turn up five to seven variants of varying concern in those two genes for the average customer.

“organic” eating may lower cancer risk after all

I haven’t always been on the “organic” band wagon 100%. For one thing, the name is stupid. Chugging a glass of diesel fuel would be about as organic as you could get, in terms of the definition of the word I learned in high school chemistry. I am strongly in favor of sustainable farming practices that build soil, protect biodiversity, and prevent groundwater and surface water pollution. But in terms of health benefits, I have never felt the benefits were all that proven, and to some extent the industry is just based on scare tactics. I also wonder if the billions of humans on the planet can be fed without resorting to fossil fuel-derived fertilizer, and I still think that is dubious. But here is one large study in JAMA that did find significant evidence of a link between organic food (as labeled at the grocery store) and reduced cancer risk.

Association of Frequency of Organic Food Consumption With Cancer Risk: Findings From the NutriNet-Santé Prospective Cohort Study

Main Outcomes and Measures This study estimated the risk of cancer in association with the organic food score (modeled as quartiles) using Cox proportional hazards regression models adjusted for potential cancer risk factors.

Results Among 68 946 participants (78.0% female; mean [SD] age at baseline, 44.2 [14.5] years), 1340 first incident cancer cases were identified during follow-up, with the most prevalent being 459 breast cancers, 180 prostate cancers, 135 skin cancers, 99 colorectal cancers, 47 non-Hodgkin lymphomas, and 15 other lymphomas. High organic food scores were inversely associated with the overall risk of cancer (hazard ratio for quartile 4 vs quartile 1, 0.75; 95% CI, 0.63-0.88; P for trend = .001; absolute risk reduction, 0.6%; hazard ratio for a 5-point increase, 0.92; 95% CI, 0.88-0.96).

Conclusions and Relevance A higher frequency of organic food consumption was associated with a reduced risk of cancer. Although the study findings need to be confirmed, promoting organic food consumption in the general population could be a promising preventive strategy against cancer.

I researched the risk measures a little. The hazard risk ratio of 0.75 means that people eating mostly organic food (scoring in the top 25% of however they are measuring that) are 25% less likely than people eating the least organic food. That seems significant. From a quick skim, it appears they did try to control for differences in lifestyle (i.e., similar nutrition and exercise levels) and family history of cancer when coming to their conclusions.

September 2018 in Review

Most frightening stories:

Most hopeful stories:

  • The Suzuki and Kodaly methods are two ways of teaching music to young children that may actually help them think later in life. Training in jazz improvisation may also be good for young brains in a slightly different way.
  • There are some bright ideas for trying to improve construction productivity, which has languished for decades. Most involve some form of offsite fabrication.
  • In energy news, there’s a big idea to produce half the world’s electricity from sunlight in the Sahara desert. Another idea for collecting solar energy in otherwise (ecologically) wasted space is solar roadways, and there are a few prototypes around the world but this doesn’t seem to be a magic bullet so far. Another big idea is long-term storage of energy to smooth out fluctuations in supply and demand over months or even years.

Most interesting stories, that were not particularly frightening or hopeful, or perhaps were a mixture of both:

the old sucking the blood of the young?

There is grisly research where a young mouse is sown together with an old mouse and their blood vessels are connected. This seems to benefit the old mouse. And no, I haven’t watched “human centipede” and I have no desire to, although I did find the South Park parody of it moderately funny.

Beyond the stupidity of human centipede, you can imagine a mad dictator or Bond villain somewhere forcing people to be blood donors against their will. A more benign version would have biotech firms trying to synthesize whatever it is that makes young blood good, or possibly using stem cells to make a young version of a person’s blood. What if a version of me could be created that was just a bag of meat with no nervous system, and pumped out blood that kept me alive? That seems creepy but not necessarily unethical. Add a brain and keep that person sedated or otherwise detained against their will, and that would clearly be unethical (not to mention basically the plot of The Island.)