“Uber for kids”

What’s the busy, car-free urban soccer mom (or dad) to do when they occasionally need to pack the kid off to a remote inaccessible (except by car) suburban area? Here’s an idea for an Uber-like service where the drivers are certified in childcare.

Parents schedule a ride with a ‘CareDriver’ and are sent a short bio for that driver, a picture, and are required to enter in a code word for the ride. The parent then relays that information to the child, and then to the school or daycare organization from which the kid is getting picked up. That way, little Tommy or Patty knows how to identify their ‘CareDriver’ through both the photo and the code word.

Parents can track the ride in real time through the app and have multiple methods of contacting the driver at any time…

All of the drivers on the platform go through a rigorous, 15-point certification process. They must have at least five years of child care service experience, alongside passing a number of background checks, criminal background checks, as well as getting fingerprinted. HopSkipDrive also ensures that their drivers are TrustLine certified, which cofounder Joanna McFarland describes as the gold standard of childcare certification in the state of California.

suburban office parks

The Washington Post covers the deflating market for suburban office parks in the D.C. area.

The building was built in 1989, and it shows: a mountain of tinted glass and beige concrete in commercial dullsville. Over the past decade, its value dropped by 64 percent. The largest tenant, the National Institutes of Health and its contractors, started packing up two years ago as leases expired. By 2014, the owner reported cash-flow problems, foreclosure arrived this past January, and that was it for 6116 Executive Blvd…

“I think, as with many other things, our younger folks are more inclined to be Metro-accessible and more urban,” Marriott chief executive Arne Sorensontold The Washington Post in March, after announcing the plans to move.

If tastes keep trending away from office parks, buildings like 6116 Executive Blvd. and 10400 Fernwood Rd. may soon be hollow, oversize memorials to the Way We Worked.

chemicals and cancer

I’ve tended not to obsess over chemicals and cancer, because I think there are other risks that are much higher and much more clearly proven (like the high odds of death every time you set foot in or anywhere near a motor vehicle, to give one example.) I also tend to accept some chemicals, like water disinfectants, food preservatives, drugs, even pesticides, as somewhat necessary evils – we actually know they have a downside, but they do more good than harm on balance. In a sense, it is a “luxury” that many of us avoid violence and infectious diseases long enough to get old and die of cancer. Cancer is at least to some extent a random phenomenon. That doesn’t mean we shouldn’t be looking for safer alternatives to these chemicals that do the same good. If we don’t look we won’t find them. And then, there are chemicals that are known to be harmful, and have no positive effects. Triclosan comes to mind. The companies using cynical fear-based marketing to force these on people should be punished.

All that aside, our food, water, air, and consumer products are full of chemicals, with the result that our bodies are full of chemicals. We don’t have good information on what most of them are doing to us, and especially what combinations of them may be doing to us. Here’s an interesting article that estimates what fraction of cancers are caused by chemicals in the environment, as opposed to lifestyle choices, genetics, and plain old bad luck.

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety ‘Mode of Action’ framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.

CRISPR

Here’s some more info on CRISPR, a genetic engineering technique some people are saying will be revolutionary.

 The Bacterial Origins of the CRISPR Genome-Editing Revolution
Sontheimer Erik J. and Barrangou Rodolphe. Human Gene Therapy. July 2015, 26(7): 413-424. doi:10.1089/hum.2015.091.

Like most of the tools that enable modern life science research, the recent genome-editing revolution has its biological roots in the world of bacteria and archaea. Clustered, regularly interspaced, short palindromic repeats (CRISPR) loci are found in the genomes of many bacteria and most archaea, and underlie an adaptive immune system that protects the host cell against invasive nucleic acids such as viral genomes. In recent years, engineered versions of these systems have enabled efficient DNA targeting in living cells from dozens of species (including humans and other eukaryotes), and the exploitation of the resulting endogenous DNA repair pathways has provided a route to fast, easy, and affordable genome editing. In only three years after RNA-guided DNA cleavage was first harnessed, the ability to edit genomes via simple, user-defined RNA sequences has already revolutionized nearly all areas of biological science. CRISPR-based technologies are now poised to similarly revolutionize many facets of clinical medicine, and even promise to advance the long-term goal of directly editing genomic sequences of patients with inherited disease. In this review, we describe the biological and mechanistic basis for these remarkable immune systems, and how their engineered derivatives are revolutionizing basic and clinical research.

condensation

Here’s an article on using condensation as a water supply. It’s a somewhat obvious idea – first, collect all that air conditioner condensate and use it for something. Second, use solar energy to condense some more.

The machine is based on Spanish technology. Local developers John Vollmer and Moses West are testing it out and allowing it to be evaluated by numerous entities, including the military.

The machine takes water from the air in the form of humidity and converts it into drinking water. It’s not a new process, but the machine does it on a large scale and much more economically than before.

“As long as you have 30 percent humidity or greater, there’s no such thing as a drought,” West said.

Lloyds of London is worried about food

Lloyds of London says we should be worried about the food supply. And yes, they have insurance for that.

Global demand for food is on the rise, driven by unprecedented growth in the world’s population and widespread shifts in consumption patterns as countries develop. The Food and Agriculture Organization (FAO) projects that global agricultural production will need to more than double by 2050 to close the gap between food supply and demand. As this chronic pressure increases, the food system is becoming increasingly vulnerable to acute shocks…

Sudden disruptions to the supply chain could reduce the global food supply and trigger a spike in food prices, leading to substantial knock-on effects for businesses and societies. The food system’s existing vulnerability to systemic shocks is being exacerbated by factors such as climate change, water stress, ongoing globalisation, and heightening political instability…

A shock to the global food supply could trigger significant claims across multiple classes of insurance, including (but not limited to) terrorism and political violence, political risk, business interruption, marine and aviation, agriculture, environmental liability, and product
liability and recall. These losses could be compounded by the potential for a food system shock to last for many years; and the ability of insurers to pay claims quickly is expected to be an important factor in post-shock recovery. More broadly, the insurance industry may also be affected by impacts on investment income and the global regulatory and business environment.

jeep hacker

Yes, hackers can really take over cars. Here’s a Wired article where it’s done on purpose.

Miller and Valasek’s full arsenal includes functions that at lower speeds fully kill the engine, abruptly engage the brakes, or disable them altogether. The most disturbing maneuver came when they cut the Jeep’s brakes, leaving me frantically pumping the pedal as the 2-ton SUV slid uncontrollably into a ditch. The researchers say they’re working on perfecting their steering control—for now they can only hijack the wheel when the Jeep is in reverse. Their hack enables surveillance too: They can track a targeted Jeep’s GPS coordinates, measure its speed, and even drop pins on a map to trace its route.

All of this is possible only because Chrysler, like practically all carmakers, is doing its best to turn the modern automobile into a smartphone. Uconnect, an Internet-connected computer feature in hundreds of thousands of Fiat Chrysler cars, SUVs, and trucks, controls the vehicle’s entertainment and navigation, enables phone calls, and even offers a Wi-Fi hot spot. And thanks to one vulnerable element, which Miller and Valasek won’t identify until their Black Hat talk, Uconnect’s cellular connection also lets anyone who knows the car’s IP address gain access from anywhere in the country. “From an attacker’s perspective, it’s a super nice vulnerability,” Miller says.

From that entry point, Miller and Valasek’s attack pivots to an adjacent chip in the car’s head unit—the hardware for its entertainment system—silently rewriting the chip’s firmware to plant their code. That rewritten firmware is capable of sending commands through the car’s internal computer network, known as a CAN bus, to its physical components like the engine and wheels. Miller and Valasek say the attack on the entertainment system seems to work on any Chrysler vehicle with Uconnect from late 2013, all of 2014, and early 2015. They’ve only tested their full set of physical hacks, including ones targeting transmission and braking systems, on a Jeep Cherokee, though they believe that most of their attacks could be tweaked to work on any Chrysler vehicle with the vulnerable Uconnect head unit. They have yet to try remotely hacking into other makes and models of cars.

James Hansen

We are expecting a “bombshell” new paper from James Hansen. According to Slate:

The study—written by James Hansen, NASA’s former lead climate scientist, and 16 co-authors, many of whom are considered among the top in their fields—concludes that glaciers in Greenland and Antarctica will melt 10 times faster than previous consensus estimates, resulting in sea level rise of at least 10 feet in as little as 50 years. The study, which has not yet been peer-reviewed, brings new importance to a feedback loop in the ocean near Antarctica that results in cooler freshwater from melting glaciers forcing warmer, saltier water underneath the ice sheets, speeding up the melting rate. Hansen, who is known for being alarmist and also right, acknowledges that his study implies change far beyond previous consensus estimates. In a conference call with reporters, he said he hoped the new findings would be “substantially more persuasive than anything previously published.” I certainly find them to be.

To come to their findings, the authors used a mixture of paleoclimate records, computer models, and observations of current rates of sea level rise, but “the real world is moving somewhat faster than the model,” Hansen says.

Hansen’s study does not attempt to predict the precise timing of the feedback loop, only that it is “likely” to occur this century. The implications are mindboggling: In the study’s likely scenario, New York City—and every other coastal city on the planet—may only have a few more decades of habitability left. That dire prediction, in Hansen’s view, requires “emergency cooperation among nations.”

War and Peace and Obama

Here is Jeffrey Sachs on Obama’s war and peace legacy:

Viewed through the lens of history, the main job of US presidents is to be mature and wise enough to stand up to the permanent war machine. Kennedy tried; his successor, Lyndon Johnson, did not, and the debacle of Vietnam ensued. Jimmy Carter tried; Reagan did not (his CIA helped to unleash death and mayhem in Central America throughout the 1980s). Clinton mostly tried (except in the Balkans); George W. Bush did not, and generated new wars and turmoil.

On the whole, Obama has tried to restrain the warmongers, yet he has given in to them frequently – not only by relying on weaponized drones, but also by waging covert wars in Syria, Libya, Yemen, Somalia, and elsewhere. Nor did he truly end the US wars in Iraq and Afghanistan; he replaced troops on the ground with US drones, air strikes, and “private” contractors.

Iran is surely his finest moment, a historic milestone that demands full-throated approval. The political difficulty of making peace with Iran is similar to that of JFK’s peacemaking with the Soviet Union in 1963.