Tag Archives: biotechnology

2023 in Review

Warning: This post is not 100% family friendly and profanity free. 2023 was just not that kind of year!

I’ll start with a personal note. After 24+ years of engineering consulting practice, I have decided to leave the world of full-time professional employment and go back to school for a bit. This is some combination of mid-life crisis and post-Covid working parent burnout. I spent a lot of time thinking about it, ran all the financial numbers, and decided I can swing it for a year or so without major implications for my eventual retirement 15-ish years down the line. So, gentle reader, you too can do this sort of thing if you want to. Just be patient, plan, prepare, do the math, and be rational about it.

The Year’s Posts

Stories I picked as “most frightening or depressing”:

  • JANUARY: How about a roundup of awful things, like the corrupt illegitimate U.S. Supreme Court, ongoing grisly wars, the CIA killed JFK after all (?), nuclear proliferation, ethnic cleansing, mass incarceration, Guantanamo Bay, and all talk no walk on climate change? And let’s hope there is a special circle of hell waiting for propaganda artists who worked for Exxon.
  • FEBRUARY: Pfizer says they are not doing gain of function research on potential extinction viruses. But they totally could if they wanted to. And this at a time when the “lab leak hypothesis” is peeking out from the headlines again. I also became concerned about bird flu, then managed to convince myself that maybe it is not a huge risk at the moment, but definitely a significant risk over time.
  • MARCH: The Covid-19 “lab leak hypothesis” is still out there. Is this even news? I’m not sure. But what is frightening to me is that deadly natural and engineered pathogens are being worked with in labs, and they almost inevitably will escape or be released intentionally to threaten us all at some point. It’s like nuclear proliferation, accidents, and terrorism – we have had a lot of near misses and a lot of luck over the last 70 years or so. Can we afford the same with biological threats (not to mention nuclear threats) – I think no. Are we doing enough as a civilization to mitigate this civilization-ending threat? I think almost certainly, obviously not. What are we doing? What are we thinking?
  • APRIL: Chemicals, they’re everywhere! And there were 20,000 accidents with them in 2022 that caused injuries, accidents, or death. Some are useful, some are risky, and some are both. We could do a better job handling and transporting them, we could get rid of the truly useless and dangerous ones, and we could work harder on finding substitutes for the useful but dangerous ones. And we could get rid of a corrupt political system where chemical companies pay the cost of running for office and then reward candidates who say and do what they are told.
  • MAY: There are more “nuclear capable states” than I thought.
  • JUNE: Most frightening and/or depressing story: Before 2007, Americans bought around 7 million guns per year. By 2016, it was around 17 million. In 2020, it was 23 million. Those are the facts and figures. Now for my opinion: no matter how responsible the vast majority of gun owners are, you are going to have a lot more suicides, homicides, and fatal accidents with so many guns around. And sure enough, firearms are now the leading cause of death in children according to CDC. That makes me sick to think about.
  • JULY: Citizens United. Seriously, this might be the moment the United States of America jumped the shark. I’ve argued in the past or Bush v. Gore. But what blindingly obvious characteristic do these two things have in common? THE CORRUPT ILLEGITIMATE UNITED STATES SUPREME COURT!!!
  • AUGUST: Immigration pressure and anti-immigration politics are already a problem in the U.S. and Europe, and climate change is going to make it worse. The 2023 WEF Global Risks Report agrees that “large scale involuntary migration” is going to be up there as an issue. We should not be angry at immigrants, we should be angry at Exxon and the rest of the energy industry, which made an intentional choice not only to directly cause all this but to prevent governments from even understanding the problem let alone doing anything to solve it. We should be very, very angry! Are there any talented politicians out there who know how to stoke anger and channel it for positive change, or is it just the evil genocidal impulses you know how to stoke?
  • SEPTEMBER: “the accumulation of physical and knowledge capital to substitute natural resources cannot guarantee green growth“. Green growth, in my own words, is the state where technological innovation allows increased human activity without a corresponding increase in environmental impact. In other words, this article concludes that technological innovation may not be able to save us. This would be bad, because this is a happy story where our civilization has a “soft landing” rather than a major course correction or a major disaster. There are some signs that human population growth may turn the corner (i.e., go from slowing down to actually decreasing in absolute numbers) relatively soon. Based on this, I speculated that “by focusing on per-capita wealth and income as a metric, rather than total national wealth and income, we can try to come up with ways to improve the quality of human lives rather than just increasing total money spent, activity, and environmental impact ceaselessly. What would this mean for “markets”? I’m not sure, but if we can accelerate productivity growth, and spread the gains fairly among the shrinking pool of humans, I don’t see why it has to be so bad.”
  • OCTOBER: Israel-Palestine. From the long-term grind of the failure to make peace and respect human rights, to the acute horror causing so much human suffering and death at this moment, to the specter of an Israeli and/or U.S. attack on Iran. It’s frightening and depressing – but of course it is not my feelings that matter here, but all the people who are suffering and going to suffer horribly because of this. The most positive thing I can think of to say is that when the dust settles, possibly years from now, maybe cooler heads will prevail on all sides. Honorable mention for most frightening story is the 2024 U.S. Presidential election starting to get more real – I am sure I and everyone else will have more to say about this in the coming (exactly one year as I write this on November 5, 2023) year!
  • NOVEMBER: An economic model that underlies a lot of climate policy may be too conservative. I don’t think this matters much because the world is doing too little, too late even according to the conservative model. Meanwhile, the ice shelves holding back Greenland are in worse shape than previously thought.
  • DECEMBER: Migration pressure and right wing politics create a toxic feedback loop practically everywhere in the world.

Stories I picked as “most hopeful”:

  • JANUARY: Bill Gates says a gene therapy-based cure for HIV could be 10-15 years away.
  • FEBRUARY:  Jimmy Carter is still alive as I write this. The vision for peace he laid out in his 2002 Nobel Peace Prize acceptance speech is well worth a read today. “To suggest that war can prevent war is a base play on words and a despicable form of warmongering. The objective of any who sincerely believe in peace clearly must be to exhaust every honorable recourse in the effort to save the peace. The world has had ample evidence that war begets only conditions that beget further war.”
  • MARCH: Just stop your motor vehicle and let elephants cross the road when and where they want to. Seriously, don’t mess with elephants.
  • APRIL: There has been some progress on phages, viruses intentionally designed to kill antibiotic-resistant bacteria. Also, anti-aging pills may be around the corner.
  • MAY: The U.S. Congress is ponying up $31 billion to give Houston a chance at a future. Many more coastal cities will need to be protected from sea level rise and intensifying storms. Now we will see if the U.S. can do coastal protection right (just ask the Dutch or Danish, no need to reinvent anything), and how many of the coastal cities it will get to before it is too late.
  • JUNE: It makes a lot of sense to tax land based on its potential developed value, whether it has been developed to that level or not. This discourages land speculation, vacant and abandoned property in cities while raising revenue that can offset other taxes.
  • JULY: There is a tiny glimmer of hope that Americans might actually value more walkable communities. And this is also a tiny glimmer of hope for the stability of our global climate, driver/bicyclist/pedestrian injuries and deaths, and the gruesome toll of obesity and diabetes. But it is only a glimmer.
  • AUGUST: Peak natural gas demand could happen by 2030, with the shift being to nuclear and renewables.
  • SEPTEMBER: Autonomous vehicles kill and maim far, far fewer human beings than vehicles driven by humans. I consider this a happy story no matter how matter how much the media hypes each accident autonomous vehicles are involved in while ignoring the tens of thousands of Americans and millions of human beings snuffed out each year by human drivers. I think at some point, insurance companies will start to agree with me and hike premiums on human drivers through the roof. Autonomous parking also has a huge potential to free up space in our urban areas.
  • OCTOBER: Flesh eating bacteria is becoming slightly more common, but seriously you are not that likely to get it. And this really was the most positive statement I could come up with this month!
  • NOVEMBER: Small modular nuclear reactors have been permitted for the first time in the United States, although it looks like the specific project that was permitted will not go through. Meanwhile construction of new nuclear weapons is accelerating (sorry, not hopeful, but I couldn’t help pointing out the contrast…)
  • DECEMBER: I mused about ways to create an early warning system that things in the world or a given country are about to go seriously wrong: “an analysis of government budgets, financial markets, and some demographic/migration data to see where various governments’ priorities lie relative to what their priorities probably should be to successfully address long-term challenges, and their likely ability to bounce back from various types and magnitudes of shock. You could probably develop some kind of risk index at the national and global levels based on this.” Not all that hopeful, you say? Well, I say it fits the mood as we end a sour year.

Stories I picked as “most interesting, not particularly frightening or hopeful, or perhaps a mixture of both”:

  • JANUARY: Genetically engineered beating pig hearts have been sown into dead human bodies. More than once.
  • FEBRUARY: It was slim pickings this month, but Jupiter affects the Sun’s orbit, just a little bit.
  • MARCHChickie Nobs have arrived!
  • APRIL: I had heard the story of the Google engineer who was fired for publicly releasing a conversation with LaMDA, a Google AI. But I hadn’t read the conversation. Well, here it is.
  • MAY: Peter Turchin’s new book proposes four indicators presaging political instability: “stagnating or declining real wages, a growing gap between rich and poor, overproduction of young graduates with advanced degrees, declining public trust, and exploding public debt“. I found myself puzzled by the “overproduction of young graduates” part, and actually had a brief email exchange with Peter Turchin himself, which I very much appreciated! Anyway, he said the problem is not education per se but “credentialism”. I have to think some more about this, but I suppose the idea is that education, like health, wealth, and almost everything else, is not equally distributed but is being horded by a particular class which is not contributing its fair share. These are my words, not Peter’s, and he might or might not agree with my characterization here.
  • JUNE: The U.S. may have alien spacecraft at Area 51 after all. Or, and this is purely my speculation, they might have discovered anti-gravity and want to throw everybody else off the scent.
  • JULY: We are all susceptible to the “end of history effect” in that we tend to assume our personalities will not change in the future, when in fact they almost certainly will. So one way to make decisions is to imagine how a few different possible future yous might look back on them.
  • AUGUST: There are a number of theories on why “western elites” have not been (perceived to be) effective in responding to crises in recent years and decades. Many have to do with institutional power dynamics, where the incentives of the individual to gain power within the institution do not align with the stated goals of the institution. Like for example, not killing everyone. The possible silver lining would be that better institutions could be designed where incentives aligned. I have an alternate, or possibly complementary, theory that there has been a decline in system thinking and moral thinking. Our leaders aren’t educated to see the systems and or think enough about whether their decisions are on the side of right or wrong.
  • SEPTEMBER: Venice has completed a major storm surge barrier project.
  • OCTOBER: The generally accepted story of the “green revolution“, that humanity saved itself from widespread famine in the face of population growth by learning to dump massive quantities of fossil fuel-derived fertilizer on farm fields, may not be fully true.
  • NOVEMBER: India somehow manages to maintain diplomatic relations with Palestine (which they recognize as a state along with 138 other UN members), Israel, and Iran at the same time.
  • DECEMBER: Did an AI named “Q Star” wake up and become super-intelligent this month?

And Now, My Brilliant Analytical Synthesis!

Climate Change. Well really, I’m likely to just say things now I have said many times before. The climate change shit is really starting to hit the fan. Our largely coastal civilization and the food supply that sustains it is at risk. The shit we can obviously see hitting the fan right now is the result of emissions years if not decades ago, and we have continued to not only emit too much but to emit too much at an increasing rate since those emissions, and we continue to not only emit too much but to emit at an increasing rate today. This means that even if we stop emitting too much right now and going forward, the crisis will continue to get worse for some time before it eventually gets better. And we are not doing that, we are continuing to not only emit too much but we are doing it at an increasing rate. We are already seeing the beginnings of massive population movements fueling a downward spiral of nationalist and outright racist geopolitics, which makes it even harder to come together and address our critical planetary carrying capacity issue in a rational manner. We are not only seeing “the return of great power competition”, we are insanely patting ourselves on the back for aiding and abetting this, and piling nuclear proliferation on top of it. Is a soft landing possible in this situation? I am not going to tell you I think it is, or even if it is possible that our species and cowards that pass for our leadership have any hope of making it happen. I think about the best we can hope for is some kind of serious but manageable collapse or crisis that brings us to our senses and allows some real leaders to emerge. To throw out one idea, maybe we could come to a new era of arms reduction for the major nuclear powers, and halts to proliferation for all the emerging nuclear powers, in exchange for civilian nuclear power for everyone who wants it, all under a strict international control and inspection regime. This would begin to address two existential risks (nuclear war and climate change) at once. Or maybe, just maybe, we are on the verge of a massive acceleration of technological progress that could make problems easier to solve. Maybe, but new technology also comes with new risks, and we shouldn’t put all our eggs in this basket. Besides, the singularity is nearing but it still feels a decade or so away to me.

UFOs. Aside from all of that, maybe the weirdest single thing going on in the world right now is the UFOs. There seems to be no real controversy about them – they are out there. They are flying around and if not defying the laws of physics as we know them, defying any technology that is able to accommodate the laws of physics as we know them. And what this logically leads to is that somebody (or some intelligent entity) knows something about the laws of physics that the rest of us do not know. Einstein explained how gravity behaves, but he wasn’t able to fully explain what gravity is or certainly how or why it came to be the way it is. Einstein’s predictions have since been proven through incontrovertible evidence, and the predictions of quantum theory have also been incontrovertibly proven, but the two theories are still at odds and in need of unification despite the efforts of the most brilliant minds today. But…are the most brilliant minds today operating in the open, or are they behind closed doors at private defense contractors and subject to censorship on national security grounds? If there has been a major discovery, would it see the light of day or would it be suppressed? I have no information here, I am just saying this is a narrative that would fit the evidence, and I don’t see other plausible narratives that fit the evidence. Why would aliens be playing with relatively easily discoverable toys in our atmosphere, while in the meantime we have discovered no radio signal evidence, no evidence of their existence in our telescopes? Those things would be very hard if not impossible to cover up, so I think we would know. The Fermi Paradox persists.

Artificial Intelligence. I tend to think the AI hype is ahead of the reality. Nonetheless, the reality is coming. It will probably seize control without our noticing after the hype has passed. Is it possible we could look back in a decade and identify 2023 as the year it woke up? There were a couple queer (in the original dictionary sense – I just couldn’t think of a better word) stories in 2023. One was a Google engineer getting fired after publicly declaring his belief that a Google AI had become conscious. The other was the “ethics board” of a major corporation firing its CEO in relation to a rumored artificial general intelligence breakthrough. Only time will tell what really happened in these cases (if it is ever made public), but one thing we can say is that technological progress does not usually go backwards.

Synthetic Biology. It’s pretty clear we are now in an age of synthetic biology breakthroughs that was hyped over the last few decades, and the media and publics of the world are predictably yawning and ignoring. But we are hearing about vaccines and cures on the horizon for diseases that have long plagued us, genetically engineered organs, synthetic meat, engineered viruses to fight antibiotic-resistant bacteria, and anti-aging pills among other things. And then there is the specter of lab accidents and biological weapons, which might be the single most scary thing in the world today out of all the terrifying things I have mentioned in this post.

2024 U.S. Presidential Election. Ugh, I’m still not ready to think about it, but it is going to happen whether I am ready to think about it or not. I’ll get around to thinking and writing about it soon, I’m sure.

Happy 2024!

once more, the lab leak hypothesis

Intercept tries to explain the recent developments on the lab leak hypothesis, but it still leaves me a bit confused. Here are the facts as I understand them:

  • In 2018, Chinese scientist Shi Zhengli, along with two U.S.-based scientists, together submitted a proposal to U.S. Department of Defense DARPA specifically about inserting a “furin cleavage site” into coronaviruses. Covid-19 has just such a furin cleavage site. This research proposal was not funded by DARPA. Shi Zhengli was known “for her work extracting samples of viruses from bats in Chinese caves”.
  • A Chinese national named Ben Hu received funding from USAID and the National Institutes of Health in 2018-2020. There were three grants in total, two of which ran from 2014-2019 and one of which was cut short in 2020 after intervention by Donald Trump. This funding “potentially” involved the furin cleavage site, but from this article at least there does not seem to be conclusive evidence.
  • The Wuhan Institute was “known for” experimenting on coronaviruses “alongside” scientists employed by the Chinese military. The article does not make any claims that Shi Zhengli or Ben Hu were employed by the Chinese military.
  • Three Wuhan Institute of Virology researchers, including Ben Hu, were hospitalized with Covid-19-like symptoms in November 2019.
  • Two investigators from the U.S. State Department spoke to “two researchers working at a US laboratory who were collaborating with the Wuhan institute at the time of the outbreak”. These sources stated that “Wuhan scientists had inserted furin cleavage sites into viruses in 2019 in exactly the way proposed in Daszak’s failed funding application to Darpa”.

So, there’s a fair amount of circumstantial evidence and second- or third-hand eyewitness accounts here. And the U.S. State Department is not averse to twisting facts to fit a narrative it thinks is in the U.S. national interest. Nonetheless, there are an awful lot of coincidences here. Maybe the U.S. government would like to pin this on the Chinese government, but there is a certain irony if they managed to f— over all of humanity together. And this would be the first plague unleashed on international humanity as a result of biological engineering.

Gary Larson, The Far Side

anti-aging pills

Anti-aging pills will hit the market in about five years, according to “an expert” named Andrew Steele. Metformin is one being mentioned. Another is a “combination of datasinib, used for chemotherapy, and quercetin, a molecule found in fruits and vegetables.” A Jeff Bezos company is working on “cell therapies that can halt and eventually reverse the process of aging.”

For my body and brain, which are both in their mid- to late-40s, the aging train seems to have left the station unfortunately. Maybe some of these things could add a few quality years for my generation, and maybe a lot more for our children and grandchildren.

March 2023 in Review

Well, I’ve finally done it to myself. My posting rate has flagged because I have overshot the limits of how much one person can reasonably do between work, family, school, and life. You can overshoot the limits for awhile, even quite a while, but eventually you pay that debt in the form of burnout at a minimum, and mental and physical and social difficulties if you wait too long to address it. Not to worry, in the medium term this problem is solvable and I will solve it. Because reading, thinking, writing, and then more thinking (mostly in that order) or very important to me. Anyway, here are some picks from the posts I did manage to make in February.

Most frightening and/or depressing story: The Covid-19 “lab leak hypothesis” is still out there. Is this even news? I’m not sure. But what is frightening to me is that deadly natural and engineered pathogens are being worked with in labs, and they almost inevitably will escape or be released intentionally to threaten us all at some point. It’s like nuclear proliferation, accidents, and terrorism – we have had a lot of near misses and a lot of luck over the last 70 years or so. Can we afford the same with biological threats (not to mention nuclear threats) – I think no. Are we doing enough as a civilization to mitigate this civilization-ending threat? I think almost certainly, obviously not. What are we doing? What are we thinking?

Most hopeful story: Just stop your motor vehicle and let elephants cross the road when and where they want to. Seriously, don’t mess with elephants.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: Chickie Nobs have arrived!

Chicken Little and Chickie-Nobs

From CBS News:

Once cells are extracted, GOOD Meat picks the cells most likely to produce healthy, sustainable and tasty meat, the company explained. The cells are immersed in nutrients inside a tank. They grow and divide, creating the cultured chicken, which can be harvested after four to six weeks.

“It’s real, delicious meat with an identical nutritional profile to conventionally raised meat but with less impact on our planet and less risk of contamination,” GOOD Meat said on its website.

GOOD Meat’s chicken is already sold in Singapore.

CBS News

The fabulous science fiction future is here! What a time to be alive!

It was a great concrete dome, concrete-floored.  Chicken Little filled most of it.  She was a gray-brown, rubbery hemisphere some fifteen yards in diameter.  Dozens of pipes ran into her pulsating flesh.  You could see that she was alive.

Herrera said to me: “All day I walk around her.  I see a part growing fast, it looks good and tender, I slice.”  His two-handed blade screamed again.  This time it shaved off an inch-thick Chicken Little steak.

Frederik Pohl, The Space Merchants, 1952

Vat-grown meat showed up in science fiction even before that.

Compare to artificial food from The World Set Free (1914) by H.G. Wells, synthetic food from Unto us a Child is Born (1933) by David H. Keller, syntho-steak from Farmer in the Sky (1950) by Robert Heinlein, vat meat from The End of the Line (1951) by James Schmitz, Chicken Little from The Space Merchants (1952) by Frederik Pohl and CM Kornbluth, carniculture plants (factories) from Four-Day Planet (1961) by H. Beam Piper, butcher plant from Time is the Simplest Thing (1961) by Clifford Simak, pseudoflesh from Whipping Star (1969) by Frank Herbert, vat-grown meat from Neuromancer (1984) by William Gibson.

http://www.technovelgy.com

What they were looking at was a large bulblike object that seemed to be covered with stippled whitish-yellow skin. Out of it came twenty thick fleshy tubes, and at the end of each tube another bulb was growing.

“What the hell is it?” said Jimmy.

“Those are chickens,” said Crake. “Chicken parts. Just the breasts, on this one. They’ve got ones that specialize in drumsticks too, twelve to a growth unit.

“But there aren’t any heads…”

“That’s the head in the middle,” said the woman. “There’s a mouth opening at the top, they dump nutrients in there. No eyes or beak or anything, they don’t need those.”

Margaret Atwood, Oryx and Crake, 2003

I like Margaret Atwood, but I still feel like she lifted that one pretty shamelessly.

The lab leak hypothesis is dead. Long live the lab leak hypothesis!

The lab leak hypothesis is back baby! Well, there is no new scientific evidence. But the U.S. “intelligence community” has now reported that it is officially split on the issue, with some agencies favoring the hypothesis. Snopes has a good explainer. The intelligence agencies’ main argument seems to be that…there is no new scientific evidence. So do the scientists and intelligence community even disagree? Or is there a science communication problem here? The scientists may be saying a natural origin is more likely than not, but the evidence is not so strong that they are willing to completely reject other hypotheses. The intelligence agencies meanwhile may have a much lower bar in terms of uncertainty, and they have an axe to grind with China. I haven’t forgotten their “intelligence assessment” of Iraq’s weapons of mass destruction, on which there was unanimous agreement.

It seems to me there are some different flavors of the lab leak hypothesis though. We know the Wuhan lab was working with bat viruses. We know they at least applied for funding at some point for genetic engineering experiments on bat viruses, because a U.S. organization was a party to that and it has been made public. We know their safety standards have been criticized. So…a lab researcher or employee could have been exposed and infected by a naturally occurring virus that was being studied there. Or they could have been exposed and infected by a genetically engineered virus that was being studied there. If the latter happened, that genetically engineered virus could have been under study for legitimate medical and public health reasons, even safety standards were inadequate. Or, maybe this is a biowarfare laboratory run by Dr. Evil. Nobody does bioweapons research by international treaty, and I just assume everybody including the United States does it.

If the problem is not the existence of adequate safety standards, but their implementation and enforcement, there are fairly obvious things that could be done to minimize the risk of a future lab leak. Training, inspections, accountability. Something akin to the IAEA’s nuclear weapons inspection regime could work. It would be in everyone’s best interests to agree and follow this course of action, right?

February 2023 in Review

Sorry to all my faithful readers worldwide (who I could undoubtedly count with the fingers of one hand with some left over) for my lengthy posting gap. Anyway, let’s have a look at what I was thinking about in February.

Most frightening and/or depressing story: Pfizer says they are not doing gain of function research on potential extinction viruses. But they totally could if they wanted to. And this at a time when the “lab leak hypothesis” is peeking out from the headlines again. I also became concerned about bird flu, then managed to convince myself that maybe it is not a huge risk at the moment, but definitely a significant risk over time.

Most hopeful story: Jimmy Carter is still alive as I write this. The vision for peace he laid out in his 2002 Nobel Peace Prize acceptance speech is well worth a read today. “To suggest that war can prevent war is a base play on words and a despicable form of warmongering. The objective of any who sincerely believe in peace clearly must be to exhaust every honorable recourse in the effort to save the peace. The world has had ample evidence that war begets only conditions that beget further war.”

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: It was slim pickings this month, but Jupiter affects the Sun’s orbit, just a little bit.

January 2023 in Review

We’re now 1/12th of the way through 2023. Is this really the fabulous science fiction future we were promised? Well, at least the Earth is not a smoking ruin, at least most parts of it.

Most frightening and/or depressing story: How about a roundup of awful things, like the corrupt illegitimate U.S. Supreme Court, ongoing grisly wars, the CIA killed JFK after all (?), nuclear proliferation, ethnic cleansing, mass incarceration, Guantanamo Bay, and all talk no walk on climate change? And let’s hope there is a special circle of hell waiting for propaganda artists who worked for Exxon.

Most hopeful story: Bill Gates says a gene therapy-based cure for HIV could be 10-15 years away.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: Genetically engineered beating pig hearts have been sown into dead human bodies. More than once.

Pfizer and “gain of function” research

This Pfizer press release just confirms that the technology to make genetically engineered viruses is widespread:

we have conducted research where the original SARS-CoV-2 virus has been used to express the spike protein from new variants of concern. This work is undertaken once a new variant of concern has been identified by public health authorities. This research provides a way for us to rapidly assess the ability of an existing vaccine to induce antibodies that neutralize a newly identified variant of concern…

In a limited number of cases when a full virus does not contain any known gain of function mutations, such virus may be engineered to enable the assessment of antiviral activity in cells. In addition, in vitro resistance selection experiments are undertaken in cells incubated with SARS-CoV-2 and nirmatrelvir in our secure Biosafety level 3 (BSL3) laboratory to assess whether the main protease can mutate to yield resistant strains of the virus.  It is important to note that these studies are required by U.S. and global regulators for all antiviral products and are carried out by many companies and academic institutions in the U.S. and around the world.

Pfizer

So they aren’t creating genetically engineered bioweapons of mass destruction, but they could if they wanted to. Somebody somewhere probably is. Not the U.S. government, which has no track record of lying or trying to dominate the world, and doesn’t collude with big business entities with the technology to do so.