Where are we on longevity?

This is a long excerpt from Peter Diamandis’s book We Are as Gods: A Survival Guide for the Age of Abundance. The New York Post somewhat amusingly did not proofread and reports the subtitle of the book as “A Survival God…” – maybe they will correct before you read this? Or maybe nobody knows or cares. Anyway, it’s sort of a cheerleading piece but I found it interesting for a run-down of some of the longevity drugs and technologies that are out there:

CRISPR lets us edit the genome; Yamanaka factors, a set of four transcription genes, roll back the biological age of cells; cellular reprogramming, epigenetic editing, mitochondrial enhancement. Each of these technologies adds more possibility, and all of them are being accelerated by AI.

Enter senolytics, a new class of drugs that clears zombie cells from our system. In mice, they’ve already extended healthspan and lifespan. Human trials are underway.

Meanwhile, companies like Celularity are working on immune reinforcement. Founded by stem cells pioneer Robert Hariri, Celularity harvests NK cells from healthy placentas and transfers them into aging bodies, where they bolster immune function. They’re also developing T cell and stem cell supplements to reboot the body’s natural repair systems. Together, these advances shift the paradigm from treating age-related disease to preventing decline before it starts.

It goes on like that, and kind of transitions from the academic research to sales pitches for various companies. Probably some of their stuff will work out and some will turn out to be snake oil.

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