Category Archives: Web Article Review

the unraveling of complex systems

This account of 96 terrible hours at JFK airport caused by terrible, but not unusually terrible, winter weather reminds us how unresilient our modern infrastructure systems can be, and how unresilient our under-maintained and investment-starved U.S. infrastructure is in particular.

By Sunday, after half a foot of snow, gale force winds, and three days of single-digit temperatures, JFK had set a new standard for air travel horrors: Travelers waited for hours or days for their flights, sitting on scavenged sheets of cardboard in their socks, fuming to nearby reporters and farflung Twitter followers. Outside, the scene was more apocalyptic. Aircraft crowded the tarmac, too many of them for the gates. Passengers were left in planes for as long as seven hours after landing. And that was a full day and a half after the cyclone bomb had dissipated.

Emperor Deterrence Has No Clothes

This long Aeon article argues that the idea of nuclear deterrence has never been shown to work, is illogical and immoral.

What we can say is that, as of this morning, those with the power to exterminate life have not done so. But this is not altogether comforting, and history is no more reassuring. The duration of ‘nuclear peace’, from the Second World War to the end of the Cold War, lasted less than five decades. More than 20 years separated the First and Second World Wars; before that, there had been more than 40 years of relative peace between the end of the Franco-Prussian War (1871) and the First World War (1914), and 55 years between the Franco-Prussian War and Napoleon’s defeat at Waterloo (1815). Even in war-prone Europe, decades of peace have not been so rare. Each time, when peace ended and the next war began, the war involved weapons available at the time – which, for the next big one, would likely include nuclear weapons. The only way to make sure that nuclear weapons are not used is to make sure that there are no such weapons. There is certainly no reason to think that the presence of nuclear weapons will prevent their use. The first step to ensuring that humans do not unleash nuclear holocaust might be to show that the Emperor Deterrence has no clothes – which would then open the possibility of replacing the illusion with something more suitable…

Even when possessed by just one side, nuclear weapons have not deterred other forms of war. The Chinese, Cuban, Iranian and Nicaraguan revolutions all took place even though a nuclear-armed US backed the overthrown governments. Similarly, the US lost the Vietnam War, just as the Soviet Union lost in Afghanistan, despite both countries not only possessing nuclear weapons, but also more and better conventional arms than their adversaries. Nor did nuclear weapons aid Russia in its unsuccessful war against Chechen rebels in 1994-96, or in 1999-2000, when Russia’s conventional weapons devastated the suffering Chechen Republic. Nuclear weapons did not help the US achieve its goals in Iraq or Afghanistan, which have become expensive catastrophic failures for the country with the world’s most advanced nuclear weapons. Moreover, despite its nuclear arsenal, the US remains fearful of domestic terrorist attacks, which are more likely to be made with nuclear weapons than be deterred by them.

In short, it is not legitimate to argue that nuclear weapons have deterred anysort of war, or that they will do so in the future. During the Cold War, each side engaged in conventional warfare: the Soviets, for example, in Hungary (1956), Czechoslovakia (1968), and Afghanistan (1979-89); the Russians in Chechnya (1994-96; 1999-2009), Georgia (2008), Ukraine (2014-present), as well as Syria (2015-present); and the US in Korea (1950-53), Vietnam (1955-75), Lebanon (1982), Grenada (1983), Panama (1989-90), the Persian Gulf (1990-91), the former Yugoslavia (1991-99), Afghanistan (2001-present), and Iraq (2003-present), to mention just a few cases.

It goes on like that. I find the arguments compelling. Still, if you are Iran, you can’t help noticing that the U.S. invaded Iraq and Libya after they were convinced to give up their nuclear weapons programs. If you are North Korea, you can’t help but notice that the U.S. has invaded several countries in Asia but is very hesitant to consider military options against you.

Norwegian immigration

Snopes.com reminds us why Norwegians are not lining up to emigrate to the United States, and in fact there is a small net flow the other way.

Emigration from Norway to the U.S. hit its peak in 1882 when almost 29,000 mostly poor Norwegians crossed the Atlantic. In 2016, however, only 1,114 Norwegians moved to the U.S., while 1,603 Americans moved to Norway…

Oil-rich Norway ranks fourth in the world for GDP per person, according to the World Bank, compared with the U.S., which was eighth. Norway also boasts a universal health care system, low unemployment and $1 trillion “rainy day” fund fueled by its offshore oil and gas resources that helps pay for generous pensions and other social welfare programs.

Norwegians also have a life expectancy of 81.8 years on average, making them the 15th longest-living people in the world, according to the World Health Organization. The U.S. is in 31st place, with a life expectancy of 79.3 years.

My experience in Norway consists of two days in Oslo. It struck me as a fairly ethically diverse place actually. It seemed gloomy, but that might have been the weather. We could definitely study and learn from the way they bank their natural resource-derived wealth for the future, and from the way they blend a thriving capitalist economy with a robust social safety net. But we won’t, because…America.

where gene therapy is heading

The “J.P. Morgan Healthcare Conference” provided some clues on where biotechnology may be going next.

After decades of setbacks, gene therapy—a loosely defined umbrella term for any technique that uses genes to treat or prevent disease—is finally here. In December, the field got its very first FDA approval with Luxturna, which corrects a defective gene in a rare, inherited retinal disease. With a half dozen more treatments in late-stage trials and an unusually open-minded FDA commissioner in Washington, the industry is expecting a flurry of new approvals this year…

Lambert’s lobbying roadmap for 2018 includes helping insurance companies understand what to do with a new gene therapy like Luxturna, which cures blindness with a single, $850,000 injection into the eye. Ranked by sticker price, it’s the most expensive medicine in America. Spark Therapeutics, the company that makes Luxturna, argues that the six-figure price tag isn’t actually that unreasonable, if you factor in all the costs that patients with the inherited retinal disease would have racked up in a lifetime of seeking better care.

But because their clinical trial patients haven’t been followed long enough to determine if the treatment benefits are actually durable for a whole lifetime, Spark has received significant pushback from insurers. As a result, the company is already exploring a some creative new pricing models. It announced last week that it’s offering a rebate program based on the treatment’s effectiveness at 30 to 90 days and again at 30 months with one East Coast provider, and is in talks about expanding it to other insurers, Spark CEO Jeffrey Marrazzo said at JPM. He said Spark is also in discussions with the Centers for Medicare and Medicaid Services on a multi-year installment plan option. Either of these could soon serve as a model for how gene therapies might be made available to patients without cutting the legs out from under the healthcare system.

The article also mentions one study that has some potentially bad news about the effectiveness of CRISPR in humans, but it sounds like the jury is still out on that.

7 wars

The Week counts and lists the number of wars the United States is currently involved in.

we’re currently at war in (at least) seven countries across the Greater Middle East: Afghanistan, Iraq, Syria, Yemen, Libya, Somalia, and Pakistan…

It would be shockingly easy for the White House and Department of Defense to do whatever they wanted with no meaningful democratic oversight at all. Our wars are fought thousands of miles from American shores with an all-volunteer force drawn from a tiny percentage of the population. Meanwhile, the country has spent the astonishing sum of $250 million a day on war-making for each of the nearly 6,000 days since the 9/11 attacks 16 years ago. Instead of raising taxes to pay for it, Congress has cut taxes, insulating the American people entirely from the cost and handing the bill to future generations of Americans in the form of debt.

Other people fight, other people suffer, other people pay — it’s a recipe for political ignorance and indifference. All the American people know is that there hasn’t been another 9/11. And that one must always, no matter what, “support the troops.” Together these sentiments translate into: “We dare not say anything critical about whatever the military is doing.” That holds for members of Congress no less than for average Americans. Rather than raise questions or concerns, we’re expected to defer. And for the most part we’re all too happy to comply with this debased and degraded form of civic duty.

I have a proposal – fund these wars through a sales tax levied very clearly on everything we buy. Every time you buy a bag of groceries, your receipt would tell you how much you contributed to the war effort. This way, those of us not fighting or sending other people to fight would at least think about it every day, and maybe be willing to speak out against it or at least make the politicians clearly explain to us why it has to be this way.

Gene Editing 2.0

Before CRISPR even becomes a household word (er, acronym?), it is already being replaced by newer and more precise methods, according to Wired.

Usually, when we’ve referred to Crispr, we’ve really meant Crispr/Cas9—a riboprotein complex composed of a short strand of RNA and an efficient DNA-cutting enzyme. It did for biology and medicine what the Model T did for manufacturing and transportation; democratizing access to a revolutionary technology and disrupting the status quo in the process. Crispr has already been used to treat cancer in humans, and it could be in clinical trials to cure genetic diseases like sickle cell anemia and beta thalassemia as soon as next year...

But this year, newer, flashier gene editing tools began rolling off the production line, promising to outshine their first-generation cousin. So if you were just getting your head around Crispr, buckle up. Because gene-editing 2.0 is here.

 

2018 transportation trends

U.S. News has predictions for transportation technology in 2018. In a nutshell, sales of electric vehicles will take off, but people will also keep buying inefficient gas vehicles because is relatively cheap right now.

According to this article, the commercial rollout of autonomous vehicles has suffered some setbacks, and 2018 might not be the big widespread adoption year.

Automated vehicle developers will push back their timelines for deployment, for good reason. Automated vehicles are coming, but the real question is when. Just over a year ago, tech magnate Elon Musk said he “felt pretty good” about a Tesla driving completely autonomously from Los Angeles to New York without any human interaction by the end of 2017. But at a recent conference, he pushed that date back another two years. Chevy delayed the debut of Super Cruise, and driverless shuttles have yet to move beyond pilot phases.

Society will greatly benefit from automated vehicle safety improvements. However, it’s a good thing that automated technologies are delayed. Automakers are finding it more difficult to design the system than they originally expected. Instead of putting a product on the road that is unsafe, they are responsibly taking the time they need to make sure the system is ready for the public. Patience will pay off in the long run.

I wonder if it is really a setback in technology, or a matter of a few high profile accidents getting a lot of media attention. Markets and regulatory agencies are going to respond to perception, no matter how clearly the statistics show that imperfect computer-controlled vehicles are a huge advance over human controlled vehicles. Insurance companies are somewhat immune to emotion and responsive to hard numbers though, so at some point when there are safer options available they may just jack rates up on people who don’t take those options. It probably won’t pay to be a late adopter.